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Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles

Title
Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles
Authors
Lee, Ga HyunLee, Sung JuneJeong, Sang WonKim, Hyun-ChulPark, Ga YoungLee, Se GeunChoi, Jin Hyun
DGIST Authors
Lee, Sung JuneJeong, Sang WonKim, Hyun-ChulLee, Se Geun
Issue Date
2016-07-01
Citation
Colloids and Surfaces B: Biointerfaces, 143, 511-517
Type
Article
Article Type
Article
Keywords
AnimalAnimalsAntagonists and InhibitorsAnti-InflammatoriesAnti-InflammatoryAnti-Inflammatory ActivityAnti-Inflammatory AgentAnti-Inflammatory AgentsAntioxidantAntioxidantsAntioxidativeBiosynthesisCell LineCell SurvivalChemistryCytologyDrug CarrierDrug CarriersDrug CompoundingDrug EffectsDrug FormulationFlavonoidsFunctional NanoparticlesIl1B Protein, MouseInterleukin-1 BetaInterleukin-6Interleukin-6, MouseMacrophageMacrophagesMetabolismMiceMicro-EmulsionMicroemulsionsMouseNanoparticleNanoparticlesOil-in-Water MicroemulsionsOxygenParticle SizePhenolsPro-Inflammatory CytokinesQuercetinSilicaSilicon DioxideSuperoxideSuperoxidesSynthesis (Chemical)Tumor Necrosis FactorTumor Necrosis Factor-AlphaUltrastructure
ISSN
0927-7765
Abstract
Utilizing the biological activities of compounds by encapsulating natural components in stable nanoparticles is an important strategy for a variety of biomedical and healthcare applications. In this study, quercetin-loaded silica nanoparticles were synthesized using an oil-in-water microemulsion method, which is a suitable system for producing functional nanoparticles of controlled size and shape. The resulting quercetin-loaded silica nanoparticles were spherical, highly monodispersed, and stable in an aqueous system. Superoxide radical scavenging effects were found for the quercetin-loaded silica nanoparticles as well as free quercetin. The quercetin-loaded silica nanoparticles showed cell viability comparable to that of the controls. The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. These results suggest that the antioxidative and antiinflammatory activities of quercetin are maintained after encapsulation in silica. Silica nanoparticles can be used for the effective and stable incorporation of biologically active natural components into composite biomaterials. © 2016 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/5095
DOI
10.1016/j.colsurfb.2016.03.060
Publisher
ELSEVIER SCIENCE BV
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles


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