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Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles
- Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles
- Lee, Ga Hyun; Lee, Sung June; Jeong, Sang Won; Kim, Hyun-Chul; Park, Ga Young; Lee, Se Geun; Choi, Jin Hyun
- DGIST Authors
- Lee, Sung June; Jeong, Sang Won; Kim, Hyun-Chul; Lee, Se Geun
- Issue Date
- Colloids and Surfaces B: Biointerfaces, 143, 511-517
- Article Type
- Animal; Animals; Antagonists and Inhibitors; Anti-Inflammatories; Anti-Inflammatory; Anti-Inflammatory Activity; Anti-Inflammatory Agent; Anti-Inflammatory Agents; Antioxidant; Antioxidants; Antioxidative; Biosynthesis; Cell Line; Cell Survival; Chemistry; Cytology; Drug Carrier; Drug Carriers; Drug Compounding; Drug Effects; Drug Formulation; Flavonoids; Functional Nanoparticles; Il1B Protein, Mouse; Interleukin-1 Beta; Interleukin-6; Interleukin-6, Mouse; Macrophage; Macrophages; Metabolism; Mice; Micro-Emulsion; Microemulsions; Mouse; Nanoparticle; Nanoparticles; Oil-in-Water Microemulsions; Oxygen; Particle Size; Phenols; Pro-Inflammatory Cytokines; Quercetin; Silica; Silicon Dioxide; Superoxide; Superoxides; Synthesis (Chemical); Tumor Necrosis Factor; Tumor Necrosis Factor-Alpha; Ultrastructure
- Utilizing the biological activities of compounds by encapsulating natural components in stable nanoparticles is an important strategy for a variety of biomedical and healthcare applications. In this study, quercetin-loaded silica nanoparticles were synthesized using an oil-in-water microemulsion method, which is a suitable system for producing functional nanoparticles of controlled size and shape. The resulting quercetin-loaded silica nanoparticles were spherical, highly monodispersed, and stable in an aqueous system. Superoxide radical scavenging effects were found for the quercetin-loaded silica nanoparticles as well as free quercetin. The quercetin-loaded silica nanoparticles showed cell viability comparable to that of the controls. The amounts of proinflammatory cytokines produced by macrophages, such as interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha, were reduced significantly for the quercetin-loaded silica nanoparticles. These results suggest that the antioxidative and antiinflammatory activities of quercetin are maintained after encapsulation in silica. Silica nanoparticles can be used for the effective and stable incorporation of biologically active natural components into composite biomaterials. © 2016 Elsevier B.V.
- ELSEVIER SCIENCE BV
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- Magnet-Controlled Materials Research Group1. Journal Articles
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