Cited 3 time in webofscience Cited 3 time in scopus

Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

Title
Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry
Authors
Ban, H. Y.Schweiger, M.Kavuri, V. C.Cochran, J. M.Xie, L.Busch, D. R.Katrasnik, J.Pathak, S.Chung, S. H.Lee, K.Choe, R.Czerniecki, B. J.Arridge, S. R.Yodh, A. G.
DGIST Authors
Lee, K.
Issue Date
2016-07
Citation
Medical Physics, 43(7), 4383-4395
Type
Article
Article Type
Article
Keywords
AgedAnatomic ModelBreast CancerBreast Cancer ImagingBreast NeoplasmsBreast TumorCancer PatientCCD-Based Optical Tomography InstrumentationChromatophoreDevicesDiagnostic ImagingDiffuse Optical TomographyEquipment DesignFemaleGeometryHumanHumansImage ReconstructionImaging PhantomImaging, Three-DimensionalMammographyModels, AnatomicNuclear Magnetic Resonance ImagingOptical MammographyOptical TomographyPhantoms, ImagingPhotonProceduresThree Dimensional ImagingTomography, OpticalTumor LocalizationValidation Study
ISSN
0094-2405
Abstract
Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated. © 2016 American Association of Physicists in Medicine.
URI
http://hdl.handle.net/20.500.11750/5098
DOI
10.1118/1.4953830
Publisher
AAPM - American Association of Physicists in Medicine
Related Researcher
  • Author Lee, Ki Joon  
  • Research Interests Biomedical Optics; DOT; DSCA; NIRS; OCT; LSCI; Nonlinear Optics; Random Laser; Coherent Backscattering
Files:
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Collection:
School of Undergraduate Studies1. Journal Articles


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