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dc.contributor.author Kim, Kang-Hoon -
dc.contributor.author Chung, Won-Seok -
dc.contributor.author Kim, Yoomi -
dc.contributor.author Kim, Ki-Suk -
dc.contributor.author Lee, In-Seung -
dc.contributor.author Park, Ji Young -
dc.contributor.author Jeong, Hyeon-Soo -
dc.contributor.author Na, Yun-Cheol -
dc.contributor.author Lee, Chang-Hun -
dc.contributor.author Jang, Hyeung-Jin -
dc.date.available 2018-01-25T01:10:11Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-08 -
dc.identifier.issn 0951-418X -
dc.identifier.uri http://hdl.handle.net/20.500.11750/5179 -
dc.description.abstract Facilitation of the wound healing process is important because a prolonged wound site increases pain and the risk of infection. In oriental medicine, an extract of Morus alba root (MA) has usually been prescribed as traditional treatment for accelerating wound healing, and it has been proven to be safe for centuries. To study the molecular mechanism of MA-mediated skin wound healing, we performed a primary cell culture and a skin explant culture and observed significant difference between the groups with and without MA extract. In the cellular system, a real-time cell analysis and real-time quantitative PCR were performed. It was found that MA extract enhanced proliferation in a dose-dependent manner on Kera-308 cell line, and up-regulated keratin expression including wound-induced Krt6a. In skin explant culture, the mRNA level derived from cell outgrowth displayed a tendency toward more up-regulated mRNA associated keratin filaments and toward a more up-regulated mRNA level of C-X-C motif chemokine 12 (CXCL12) and a chemokine receptor 4 (CXCR4) axis signaling pathway downstream. In this process, we concluded that MA extract had a scientific possibility of wound repair by increasing intracellular and extracellular supports and by inducing a CXCL12/CXCR4 signaling pathway. © 2015 John Wiley & Sons, Ltd. -
dc.publisher Wiley Blackwell -
dc.title Transcriptomic Analysis Reveals Wound Healing of Morus alba Root Extract by Up-Regulating Keratin Filament and CXCL12/CXCR4 Signaling -
dc.type Article -
dc.identifier.doi 10.1002/ptr.5375 -
dc.identifier.scopusid 2-s2.0-84938751746 -
dc.identifier.bibliographicCitation Phytotherapy Research, v.29, no.8, pp.1251 - 1258 -
dc.subject.keywordAuthor Morus alba root -
dc.subject.keywordAuthor therapeutic treatment -
dc.subject.keywordAuthor C-X-C motif chemokine 12 (CXCL12) -
dc.subject.keywordAuthor chemokine receptor 4 (CXCR4) -
dc.subject.keywordPlus Animal -
dc.subject.keywordPlus Animal Cell -
dc.subject.keywordPlus Animal Experiment -
dc.subject.keywordPlus Animal Model -
dc.subject.keywordPlus Animals -
dc.subject.keywordPlus APOPTOSIS -
dc.subject.keywordPlus Article -
dc.subject.keywordPlus C-X-C Motif Chemokine 12 (CXCL12) -
dc.subject.keywordPlus Cell Cycle -
dc.subject.keywordPlus Cell Differentiation -
dc.subject.keywordPlus Cell Growth -
dc.subject.keywordPlus Cell Line -
dc.subject.keywordPlus Cell Migration -
dc.subject.keywordPlus Cell Proliferation -
dc.subject.keywordPlus Cell Viability -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus Chemistry -
dc.subject.keywordPlus Chemokine CXCL12 -
dc.subject.keywordPlus Chemokine Receptor 4 (CXCR4) -
dc.subject.keywordPlus Chemokine Receptor CXCR4 -
dc.subject.keywordPlus CHemOKINE RECEPTORS -
dc.subject.keywordPlus Controlled Study -
dc.subject.keywordPlus CXCL12 Protein, Mouse -
dc.subject.keywordPlus CXCR4 Protein, Mouse -
dc.subject.keywordPlus Cytokeratin 14 -
dc.subject.keywordPlus Cytokeratin 6 -
dc.subject.keywordPlus Cytokeratin 6A -
dc.subject.keywordPlus Cytology -
dc.subject.keywordPlus Down Regulation -
dc.subject.keywordPlus Drug Effects -
dc.subject.keywordPlus Drug Efficacy -
dc.subject.keywordPlus Drug Mechanism -
dc.subject.keywordPlus DYNAMICS -
dc.subject.keywordPlus Extracellular Matrix -
dc.subject.keywordPlus HAIR FOLLICLE -
dc.subject.keywordPlus Immune Response -
dc.subject.keywordPlus In Vitro Study -
dc.subject.keywordPlus In Vitro Techniques -
dc.subject.keywordPlus Institute For Cancer Research Mouse -
dc.subject.keywordPlus INTERMEDIATE-FILAMENTS -
dc.subject.keywordPlus Keratin -
dc.subject.keywordPlus Keratinocyte -
dc.subject.keywordPlus Keratinocytes -
dc.subject.keywordPlus Keratins -
dc.subject.keywordPlus Lipid Metabolism -
dc.subject.keywordPlus Messenger RNA -
dc.subject.keywordPlus Metabolism -
dc.subject.keywordPlus Mice -
dc.subject.keywordPlus Mice, Inbred ICR -
dc.subject.keywordPlus Morus -
dc.subject.keywordPlus Morus Alba -
dc.subject.keywordPlus Morus Alba Root -
dc.subject.keywordPlus Mouse -
dc.subject.keywordPlus Mulberry Extract -
dc.subject.keywordPlus Nonhuman -
dc.subject.keywordPlus Plant Extract -
dc.subject.keywordPlus Plant Extracts -
dc.subject.keywordPlus Plant Root -
dc.subject.keywordPlus Plant Roots -
dc.subject.keywordPlus Primary Cell Culture -
dc.subject.keywordPlus Protein Expression -
dc.subject.keywordPlus Protein Function -
dc.subject.keywordPlus Receptors, CXCR4 -
dc.subject.keywordPlus REGENERATION -
dc.subject.keywordPlus RNA, Messenger -
dc.subject.keywordPlus Signal Transduction -
dc.subject.keywordPlus Skin -
dc.subject.keywordPlus SMALL GTPASES -
dc.subject.keywordPlus Stromal Cell Derived Factor 1 -
dc.subject.keywordPlus Therapeutic Treatment -
dc.subject.keywordPlus Transcriptome -
dc.subject.keywordPlus Unclassified Drug -
dc.subject.keywordPlus Up-Regulation -
dc.subject.keywordPlus Wound Healing -
dc.citation.endPage 1258 -
dc.citation.number 8 -
dc.citation.startPage 1251 -
dc.citation.title Phytotherapy Research -
dc.citation.volume 29 -
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Appears in Collections:
Department of New Biology Biointerface Structure and Skin Lab 1. Journal Articles
School of Undergraduate Studies 1. Journal Articles

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