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dc.contributor.author Kim, Hyun-Chul -
dc.contributor.author Kim, Eunjoo -
dc.contributor.author Ha, Tae-Lin -
dc.contributor.author Jeong, Sang Won -
dc.contributor.author Lee, Se Guen -
dc.contributor.author Lee, Sung Jun -
dc.contributor.author Lee, Boram -
dc.date.accessioned 2018-01-25T01:10:37Z -
dc.date.available 2018-01-25T01:10:37Z -
dc.date.created 2017-04-10 -
dc.date.issued 2015-03-01 -
dc.identifier.issn 0927-7765 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/5200 -
dc.description.abstract Thiol-responsive gemini micelles consisting of hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic polylactide (PLA) blocks with a cystine disulfide spacer were reported as effective intracellular nanocarriers of drugs. In the presence of cellular glutathione (GSH) as a reducing agent, gemini micelles gradually destabilize into monomeric micelles through cleavage of the cystine linkage. This destabilization of the gemini micelles changed their size distribution, with the appearance of small aggregates, and led to the enhanced release of encapsulated doxorubicin (DOX). The results obtained from cell culture via confocal laser scanning microscopy (CLSM) for cellular uptake, as well as cell viability measurements for anticancer efficacy suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers. © 2015 Elsevier B.V. -
dc.publisher Elsevier B.V. -
dc.title Thiol-responsive gemini poly(ethylene glycol)-poly(lactide) with a cystine disulfide spacer as an intracellular drug delivery nanocarrier -
dc.type Article -
dc.identifier.doi 10.1016/j.colsurfb.2015.01.039 -
dc.identifier.scopusid 2-s2.0-84922433319 -
dc.identifier.bibliographicCitation Colloids and Surfaces B: Biointerfaces, v.127, pp.206 - 212 -
dc.subject.keywordAuthor Gemini surfactants -
dc.subject.keywordAuthor Drug delivery systems -
dc.subject.keywordAuthor Micelles -
dc.subject.keywordAuthor Disulfide-thiol exchange -
dc.subject.keywordAuthor Biodegradable -
dc.subject.keywordAuthor Stimulus-sensitive polymers -
dc.subject.keywordPlus BIOREDUCIBLE MICELLES -
dc.subject.keywordPlus DIBLOCK COPOLYMER -
dc.subject.keywordPlus BLOCK-COPOLYMERS -
dc.subject.keywordPlus SURFACTANTS -
dc.subject.keywordPlus BEHAVIOR -
dc.subject.keywordPlus SOLUBILIZATION -
dc.subject.keywordPlus PLATFORM -
dc.subject.keywordPlus RELEASE -
dc.subject.keywordPlus CELLS -
dc.subject.keywordPlus DYES -
dc.citation.endPage 212 -
dc.citation.startPage 206 -
dc.citation.title Colloids and Surfaces B: Biointerfaces -
dc.citation.volume 127 -

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