Cited 19 time in webofscience Cited 19 time in scopus

Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappa B signaling in MCF-7 breast cancer cells

Title
Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappa B signaling in MCF-7 breast cancer cells
Authors
Park, Su-HoKim, Jung-HeeLee, Dong-HunKang, Jeong-WooSong, Hyuk-HwanOh, Sei-RyangYoon, Do-Young
Issue Date
2013-11
Citation
Biochimie, 95(11), 2082-2090
Type
Article
Article Type
Article
Keywords
Activator Protein-1Antineoplastic ActivityAP-1Breast CancerBreast NeoplasmsCancer CellCancer InhibitionCancer InvasionCell FractionationCell InvasionCell MigrationCell MotilityCell Strain MCF 7Cell ViabilityConcentration ResponseControlled StudyCytokine ReleaseDown-RegulationEnzyme ActivationEnzyme PhosphorylationERKExtracellular Signal-Regulated Protein KinaseFemaleFlavonoidGelatinase BGene Expression Regulation, NeoplasticHumanHuman CellHumansIL-8ImmunofluorescenceImmunoglobulin Enhancer Binding ProteinInterleukin-8LuteolinLuteolin 8 C Beta FucopyranosideMap Kinase Signaling SystemMatrix Metalloproteinase-9MCF-7 CellsMitogen-Activated Protein KinaseMitogen-Activated Protein Kinase P38MMP-9NF-Kappa Bnuclear factor-Kappa BPhorbol 13 Acetate 12 MyristateProtein ExpressionProtein PhosphorylationProtein SubunitPyranosideReverse Transcriptase-Polymerase Chain ReactionSignal TransductionStress Activated Protein KinaseTetradecanoylphorbol AcetateTranscription Factor AP-1Tumor InvasionUnclassified DrugWound HealingZymography
ISSN
0300-9084
Abstract
Matrix metalloproteinase 9 (MMP-9) and interleukin-8 (IL-8) play major roles in tumor progression and invasion of breast cancer cells. The present study was undertaken to investigate the inhibitory mechanism of cell invasion by luteolin 8-C-β-fucopyranoside (named as LU8C-FP), a C-glycosylflavone, in human breast cancer cells. We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells. LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-κB. TPA-induced phosphorylation of ERK 1/2 was suppressed by LU8C-FP, whereas JNK and p38 MAPK phosphorylation were unaffected. In addition, LU8C-FP blocked the ERK 1/2 pathways following expression of MMP-9 and IL-8. These results suggest LU8C-FP may function to suppress invasion of breast cancer cells through the ERK/AP-1 and ERK/NF-κB signaling cascades. © 2013 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/5295
DOI
10.1016/j.biochi.2013.07.021
Publisher
Elsevier
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


qrcode mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE