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Neural tracts injuries in patients with hypoxic ischemic brain injury: Diffusion tensor imaging study

Title
Neural tracts injuries in patients with hypoxic ischemic brain injury: Diffusion tensor imaging study
Authors
Lee, Ah YoungShin, Dong-GuPark, Jong-SeonHong, Geu RuChang, Pyung-HunSeo, Jeong PyoJang, Sung Ho
Issue Date
2012-10-18
Citation
Neuroscience Letters, 528(1), 16-21
Type
Article
Article Type
Article
Keywords
AdolescentAdultAlertnessAwarenessBrainBrain FornixCingulate GyrusClinical ArticleControlled StudyDiffusion CoefficientDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingDisease SeverityFemaleFractional AnisotropyHumanHumansHypoxia-Ischemia, BrainHypoxic Ischemic Brain InjuryHypoxic Ischemic EncephalopathyMaleMedial Longitudinal FasciculusMiddle AgedNervous System InjuryNeural PathwaysNeural TractPriority JournalPyramidal TractRadiationVoxel Based MorphometryYoung Adult
ISSN
0304-3940
Abstract
Many studies have reported on vulnerable areas of the brain in hypoxic ischemic brain injury (HI-BI). However, little is known about the involvement of neural tracts following HI-BI. We investigated neural tract injuries in adult patients with HI-BI, using diffusion tensor tractography (DTT). Twelve consecutive patients with HI-BI and 12 control subjects were recruited for this study. We classified the patients into two subgroups according to the preservation of alertness: subgroup A-5 patients who had intact alertness and subgroup B-7 patients who had impaired alertness. DTI-Studio software was used for evaluation of seven neural tracts: corticospinal, cingulum, fornix, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and optic radiation. We measured the DTT parameters (fractional anisotropy, apparent diffusion coefficient and voxel number) of each neural tract. In the individual analysis, all 12 patients showed injuries in all 24 neural tracts in terms of both DTT parameters and integrity, except for the corticospinal tract (75.0% injury). In the group analysis, the patient group showed neural injuries in all 24 neural tracts. In comparison of subgroups A and B, subgroup B showed more severe injuries: subgroup B showed a higher rate of disruption (39.8%) than subgroup A (12.9%) on individual DTTs and subgroup B had more severe injuries in both the cingulum and superior longitudinal fasciculus. In conclusion, we found that extensive injuries in the neural tracts were accompanied by HI-BI. Patients with impaired alertness appeared to show more severe injuries of neural tracts. © 2012 Elsevier Ireland Ltd.
URI
http://hdl.handle.net/20.500.11750/5348
DOI
10.1016/j.neulet.2012.08.053
Publisher
Elsevier Ltd
Files:
There are no files associated with this item.
Collection:
ETC1. Journal Articles


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