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Jazf1 promotes prostate cancer progression by activating JNK/Slug

Title
Jazf1 promotes prostate cancer progression by activating JNK/Slug
Authors
Sung, Yong HunPark, SongPark, Si JunJeong, Ja InChoi, Min JeeLee, Jin HeeKwon, Wook BongJang, So YoungLee, Mee HyunKim, Dong JoonLiu, Kang DongKim, Sung HyunLee, Jae HoHa, Yun SokKwon, Tae GyunLee, Sang GyuDong, ZigangRyoo, Zae YoungKim, Myoung Ok
Issue Date
2018-01
Citation
Oncotarget, 9(1), 755-765
Type
Article
Article Type
Article
Keywords
EPITHELIAL-MESENCHYMAL TRANSITIONTUMOR PROGRESSIONBREAST-CANCERCELL INVASIONIN-VITRORECEPTORSLUGMETASTASISGENESEMT
ISSN
1949-2553
Abstract
Juxtaposed with another zinc finger protein 1 (Jazf1) is a zinc finger protein and is known to affect both prostate cancer and type 2 diabetes. Jazf1 inhibits testicular nuclear receptor 4 (TR4) activation through protein-protein interaction, which results in weight loss and alleviates diabetes. However, the role of Jazf1 in prostate cancer is still poorly understood. Hence, we investigated whether the expression of Jazf1 is associated with prostate cancer progression. We confirmed the upregulation of Jazf1 expression in human prostate tissue samples. In addition, using Jazf1 overexpressing prostate cancer cell lines, DU145 and LNCaP, we found Jazf1 promoted cell proliferation and colony formation ability. We also observed that Jazf1 dramatically enhanced cell migration and invasion in transwell assays. Additionally, we checked the upregulation of vimentin and downregulation of E-cadherin expression in Jazf1- overexpressing DU145 and LNCaP cells. Moreover, we found that Slug, which is known to be regulated by JNK/c-Jun phosphorylation, was upregulated in the microarray analysis of two prostate cancer cell lines. Jazf1 promotes the phosphorylation of JNK/ c-Jun, likely promoting cell proliferation and invasion through Slug. In a xenograft model, tumors overexpressing Jazf1 were larger than control tumors, and tumors with decreased Jazf1 were smaller. These data indicated that Jazf1 enhances prostate cancer progression and metastasis via regulating JNK/Slug signaling. Taken together, these results suggest that Jazf1 plays an important role in both androgen dependent and independent prostate cancer. © Sung et al.
URI
http://hdl.handle.net/20.500.11750/5595
DOI
10.18632/oncotarget.23146
Publisher
IMPACT JOURNALS LLC
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