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Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits

Title
Roles of Glial Cells in Sculpting Inhibitory Synapses and Neural Circuits
Authors
Um, Ji Won
DGIST Authors
Um, Ji Won
Issue Date
2017-11
Citation
Frontiers in Molecular Neuroscience, 10
Type
Article
Article Type
Review
Keywords
OLIGODENDROCYTE PRECURSOR CELLSRAT HIPPOCAMPAL-NEURONSKEY METABOLIC ENZYMESEXTRACELLULAR-MATRIXSYNAPTIC-TRANSMISSIONPERINEURONAL NETSMICROGLIA ACTIVATIONINTERNEURON NETWORKSMEDIATED MODULATIONCNS SYNAPTOGENESIS
ISSN
1662-5099
Abstract
Glial cells are essential for every aspect of normal neuronal development, synapse formation, and function in the central nervous system (CNS). Astrocytes secrete a variety of factors that regulate synaptic connectivity and circuit formation. Microglia also modulate synapse development through phagocytic activity. Most of the known actions of CNS glial cells are limited to roles at excitatory synapses. Nevertheless, studies have indicated that both astrocytes and microglia shape inhibitory synaptic connections through various mechanisms, including release of regulatory molecules, direct contact with synaptic terminals, and utilization of mediators in the extracellular matrix. This review summarizes recent investigations into the mechanisms underlying CNS glial cell-mediated inhibitory synapse development.
URI
http://hdl.handle.net/20.500.11750/5637
DOI
10.3389/fnmol.2017.00381
Publisher
FRONTIERS MEDIA SA
Related Researcher
  • Author Um, Ji Won Um Laboratory
  • Research Interests Molecular and cellular mechanisms underlying synapse elimination; Key synaptic mechanisms associated with Alzheimer's disease and autism spectrum disorders; Synaptic homeostasis
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesUm Laboratory1. Journal Articles


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