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생리활성이 향상된 수술용 메시

Title
생리활성이 향상된 수술용 메시
Translated Title
Bioactivity-enhanced Surgical Mesh
Authors
이성준이가현최진현최교창이세근김한도박홍수
DGIST Authors
이성준이세근
Issue Date
2009
Citation
생체재료학회지, 13(2), 70-75
Type
Article
Keywords
BioactiveSurgical meshAnti-oxidantAnti-inflammation
ISSN
1226-4601
Abstract
Polypropylene (PP) mesh has been widely used for surgical treatment of urinary incontinence. Despite of the undisputed advantages of the PP meshes currently available, there have been number of reports about complications after these surgeries such as inflammation and infection around implanted area. Anti-oxidant agents including caffeic acid, quercetin, morin, and curcumin were incorporated to the surface of PP films to depress an initial excessive inflammatory reaction through quenching reactive oxygen species(ROS) released from macrophages. The depression of the inflammation could be evaluated through measuring various cytokines produced by LPS-stimulated macrophages, and quercetin-coated PP film which had the highest ROS scavenging activity among other anti-oxidants showed decreases in IL-1β and IL-6 by 68% and 77% compared to control, respectively. Furthermore, the viabilities of fibroblasts cultured on the anti-oxidant-coated PP films were increased and abundant spreading of cell were observed in SEM micrographs. From these results, it could be suggested that the incorporation of anti-oxidant would be one of the promising methods to enhance anti-inflammation and cell-affinity of surgical meshes.
URI
http://hdl.handle.net/20.500.11750/5735
Publisher
한국생체재료학회
Related Researcher
Files:
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Collection:
Magnet-Controlled Materials Research Group1. Journal Articles


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