Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Eunkyeong | - |
dc.contributor.author | Kang, Changsun | - |
dc.contributor.author | Lee, Jeonghun | - |
dc.contributor.author | Yoo, Donghyuck | - |
dc.contributor.author | Hwang, Do Won | - |
dc.contributor.author | Kim, Dohyun | - |
dc.contributor.author | Park, Seong-Cheol | - |
dc.contributor.author | Lim, Sang Kyoo | - |
dc.contributor.author | Song, Chulgyu | - |
dc.contributor.author | Lee, Dongwon | - |
dc.date.available | 2018-02-26T08:44:09Z | - |
dc.date.created | 2018-02-22 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | ACS Nano, v.12, no.1, pp.392 - 401 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5882 | - |
dc.description.abstract | A thrombus (blood clot), composed mainly of activated platelets and fibrin, obstructs arteries or veins, leading to various life-threatening diseases. Inspired by the distinctive physicochemical characteristics of thrombi such as abundant fibrin and an elevated level of hydrogen peroxide (H2O2), we developed thrombus-specific theranostic (T-FBM) nanoparticles that could provide H2O2-triggered photoacoustic signal amplification and serve as an antithrombotic nanomedicine. T-FBM nanoparticles were designed to target fibrin-rich thrombi and be activated by H2O2 to generate CO2 bubbles to amplify the photoacoustic signal. In the phantom studies, T-FBM nanoparticles showed significant amplification of ultrasound/photoacoustic signals in a H2O2-triggered manner. T-FBM nanoparticles also exerted H2O2-activatable antioxidant, anti-inflammatory, and antiplatelet activities on endothelial cells. In mouse models of carotid arterial injury, T-FBM nanoparticles significantly enhanced the photoacoustic contrast specifically in thrombosed vessels and significantly suppressed thrombus formation. We anticipate that T-FBM nanoparticles hold great translational potential as nanotheranostics for H2O2-associated cardiovascular diseases. © 2017 American Chemical Society. | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.title | Molecularly Engineered Theranostic Nanoparticles for Thrombosed Vessels: H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsnano.7b06560 | - |
dc.identifier.wosid | 000423495200042 | - |
dc.identifier.scopusid | 2-s2.0-85042191189 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | ACS Nano | - |
dc.contributor.nonIdAuthor | Jung, Eunkyeong | - |
dc.contributor.nonIdAuthor | Kang, Changsun | - |
dc.contributor.nonIdAuthor | Lee, Jeonghun | - |
dc.contributor.nonIdAuthor | Yoo, Donghyuck | - |
dc.contributor.nonIdAuthor | Hwang, Do Won | - |
dc.contributor.nonIdAuthor | Kim, Dohyun | - |
dc.contributor.nonIdAuthor | Park, Seong-Cheol | - |
dc.contributor.nonIdAuthor | Song, Chulgyu | - |
dc.contributor.nonIdAuthor | Lee, Dongwon | - |
dc.identifier.citationVolume | 12 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationStartPage | 392 | - |
dc.identifier.citationEndPage | 401 | - |
dc.identifier.citationTitle | ACS Nano | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordAuthor | thrombus | - |
dc.subject.keywordAuthor | photoacoustic imaging | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | theranostic | - |
dc.subject.keywordAuthor | antithrombotic | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PLATELETS | - |
dc.subject.keywordPlus | AGENT | - |
dc.contributor.affiliatedAuthor | Jung, Eunkyeong | - |
dc.contributor.affiliatedAuthor | Kang, Changsun | - |
dc.contributor.affiliatedAuthor | Lee, Jeonghun | - |
dc.contributor.affiliatedAuthor | Yoo, Donghyuck | - |
dc.contributor.affiliatedAuthor | Hwang, Do Won | - |
dc.contributor.affiliatedAuthor | Kim, Dohyun | - |
dc.contributor.affiliatedAuthor | Park, Seong-Cheol | - |
dc.contributor.affiliatedAuthor | Lim, Sang Kyoo | - |
dc.contributor.affiliatedAuthor | Song, Chulgyu | - |
dc.contributor.affiliatedAuthor | Lee, Dongwon | - |
There are no files associated with this item.