https://scholar.dgist.ac.kr/handle/20.500.11750/10012 2026-10-04T00:11:11Z https://scholar.dgist.ac.kr/handle/20.500.11750/60904 Title: Equilibrium-driven decarbonylative multi-deuteration enables access to highly deuterated carbon frameworks Author(s): Lee, Jiin; Park, Taejun; Park, Jeong Eun; Moon, Hye Won; Lee, Sunggi Abstract: Deuterium incorporation is a powerful strategy for modulating metabolic stability and probing reaction mechanisms. However, existing approaches based on defunctionalization or hydrogen-deuterium exchange are typically limited to mono-deuteration or suffer from poor site selectivity, restricting access to multi-deuterated carbon centers. Herein, we report a cost-effective strategy for decarbonylative multi-deuteration of aldehydes by integrating polar alpha-deuteration, thiyl radical-mediated hydrogen atom transfer (HAT), and decarbonylative deuteration. A key feature of this approach is an equilibrium-controlled radical-polar process, in which multiple reversible steps are directed toward productive pathways through irreversible trapping of alkyl radicals. The method employs inexpensive, commercially available reagents and exhibits a broad substrate scope encompassing primary, secondary, and tertiary aldehydes, including structurally complex substrates. This strategy provides a practical platform for the synthesis of highly deuterated carbon frameworks, offering new opportunities for isotopic labeling and medicinal chemistry. 2026-08-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60428 Title: 브롬 화합물의 중수소화 방법, 이에 사용되는 중수소화 용액 및 이를 이용하여 제조된 중수소화물 Author(s): 이성기; 이지인 Abstract: 본 발명은 브롬 화합물의 중수소화 방법, 이에 사용되는 중수소화 용액 및 이를 이용하여 제조된 중수소화물을 개시한다. 본 발명은 브롬 화합물, 이황화물(disulfide), 실란 화합물(silane compound), 중수(D2O) 및 용매를 혼합하여 중수소화 용액을 제조하는 단계; 가시광선 조사 하에 상기 중수소화 용액을 교반하여 중수소화물을 제조하는 단계;를 포함하는 것을 특징으로 한다. https://scholar.dgist.ac.kr/handle/20.500.11750/60204 Title: Light-driven silane functionalization using disulfide and dichloromethane Author(s): Lee, Jiin; Kim, Hyunji; Lee, Sunggi Abstract: Organosilicon compounds are of great importance in material and synthetic chemistry. Herein, we disclose a practical and general silane functionalization protocol that enables direct access to silanols and silyl ethers. The process features mild, environmentally benign conditions and enables the transformation of diverse silanes into valuable organosilicon compounds. 2026-02-28T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60030 Title: Cyclopropanation of Alkenes with Dichloromethane and Chloroform via Halogen Atom Transfer Using Amine Carboxyborane Author(s): Park, Changhee; Lee, Sunggi Abstract: Cyclopropanes are privileged motifs in medicinal chemistry due to their role as bioisosteres of arenes, alkenes, and small alkyl groups. Herein, we report a transition-metal-free, photoredox-catalyzed cyclopropanation of diverse alkenes via halogen atom transfer between dichloromethane (CH2Cl2) as a C1 synthon and amine-ligated boryl radicals generated from amine carboxyborane. This method proceeds under mild reaction conditions, exhibits a broad substrate scope, and is scalable. The synthetic utility is further highlighted by deuterium incorporation using CD2Cl2 and the formation of chlorocyclopropane products using chloroform (CHCl3) and CDCl3, enabling access to valuable chlorinated and isotopically labeled cyclopropanes. 2025-11-30T15:00:00Z