https://scholar.dgist.ac.kr/handle/20.500.11750/10138 2026-10-10T19:26:32Z https://scholar.dgist.ac.kr/handle/20.500.11750/60915 Title: 메플로퀸 또는 이의 유도체를 포함하는 신장 질환의 치료용 조성물 Author(s): 이경민; 황여진 Abstract: 본 발명은 메플로퀸 (Mefloquine) 또는 이의 유도체를 포함하는 신장 질환의 치료용 조성물에 관한 것으로, 더욱 상세하게는 신장 섬유화 인자의 유전자 또는 단백질 발현 수준을 억제하는 메플로퀸에 관한 것이다. https://scholar.dgist.ac.kr/handle/20.500.11750/60908 Title: 메틱센 또는 이의 약제학적으로 허용 가능한 염을 포함하는 신장 질환의 치료용 조성물 Author(s): 황여진; 이경민 Abstract: 본 발명의 일실시예는 메틱센 (Metixene) 또는 이의 약제학적으로 허용 가능한 염을 포함하는 신장 질환의 치료용 조성물에 관한 것으로, 더욱 상세하게는 신장 섬유화 인자의 유전자 또는 단백질 발현 수준을 억제하는 메틱센에 관한 것이다. https://scholar.dgist.ac.kr/handle/20.500.11750/60897 Title: A Steerable and Expandable Magnetic Aspiration Catheter for Enhanced Aspiration Thrombectomy Author(s): Lee, Hakjoon; Dong, Xiao; Kim, Dong-in; Chowdhury, A. M. Masum Bulbul; Gharamaleki, Nader Latifi; Kim, Jin-young; Youn, Sung Won; Choi, Hongsoo Abstract: Aspiration thrombectomy is widely used when treating acute ischemic stroke. A blood clot is directly suctioned through a catheter connected to a vacuum system. Although an increase in catheter bore size significantly enhances aspiration efficiency, this compromises endovascular navigability during manual manipulation. To minimize this trade-off, this paper presents a novel, magnetic aspiration catheter that enables both active steering and distal-end expansion via externally applied magnetic fields. The catheter incorporates dual-axis magnetization. Axial magnetization facilitates directional steering by aligning the catheter tip with the magnetic field; radial magnetization enables dynamic expansion of the cross-sectional area in response to the field strength, thereby improving clot contact and reducing leakage between the catheter and vessel wall. A magnetic mold-based fabrication method is employed to realize such dual-axis magnetization. The magnetically actuated motions of the catheter are theoretically and experimentally validated. Active steering reduces the navigation time by 67.5% (30.3 vs. 93.1 s) and expansion increases the aspiration force by 430% (27 vs. 143 & micro;N). Catheter efficacy and feasibility in terms of aspiration thrombectomy are demonstrated using 3D vascular phantoms. By enhancing both navigational control and therapeutic performance, this study advances the development of practical robotic systems for rapid and precise stroke treatment. 2026-06-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60879 Title: Magnetic Control of Intravascular Collaborative Robotic (Cobot) Guidewire: Neurovascular Intervention Studies in Phantom and Swine Models Author(s): Kim, Dong-in; Kim, Beomjoo; Lee, Hakjoon; Hwang, Junsun; Jeon, Sungwoong; Kim, Jin-young; Youn, Sung Won; Choi, Hongsoo Abstract: Strokes such as acute ischemic stroke require vascular access for endovascular thrombectomy. To navigate the small and complex cerebral vessels with multiple branches, clinicians use guidewires or catheters with pre-shaped tips. However, complex procedures still face the problem of increased X-ray exposure for both clinicians and patients. Engineering technologies such as robotic guidewires and catheters are being applied to neurovascular procedures to make them faster and more effective. The technology presented in this study involves Collaborative Robotic (Cobot) guidewires that can be steered by magnetic fields to effectively enter the target vessel and navigate complex blood vessels. The Cobot guidewire can be steered according to the direction of the magnetic field because its tip contains a permanent magnet and a magnetic polymer. The magnetic field for steering the Cobot guidewire can be controlled and generated by electromagnetic control systems (ECS). In this study, the performance of neurovascular procedures using the Cobot guidewire and manual guidewire is compared in both phantom and swine models. Based on various parameters, the Cobot guidewire demonstrates superior performance in neurovascular procedures compared to the manual guidewire. Favorable procedure time and navigation efficiency suggest that a magnetically assisted Cobot guidewire is potentially feasible for neurovascular interventions. 2026-06-30T15:00:00Z