https://scholar.dgist.ac.kr/handle/20.500.11750/10138 2026-08-10T16:19:32Z https://scholar.dgist.ac.kr/handle/20.500.11750/60592 Title: Polystyrene Nanoplastics Exacerbate CCl4-Induced Liver Fibrosis by Aggravating Stretch-Induced Mechanical Stress in Hepatic Stellate Cells Author(s): Yim, Jae-Hyuk; Kim, Tae-Un; Kim, Woo Jun; Kim, Hee-Yeon; Lee, Seoung-Woo; Kang, Kyung-Ku; Seo, Min-Soo; Kim, Sung Dae; Cho, Young-Eun; Baek, Su-Min; Choi, Seong-Kyoon; Park, Jin-Kyu Abstract: Although studies on the potential hepatotoxicity of nanoplastic depositions are being conducted, there remains a lack of research on the association between nanoplastic depositions and chronic liver disease. Therefore, this research aimed to explore the influence of polystyrene nanoparticles (PS-NPs) on the progression of liver fibrosis and the mechanisms involved in the hepatic stellate cells (HSCs) activation. Chronic exposure to PS-NPs aggravated CCl4-induced liver fibrosis, as evidenced by enhanced collagen accumulation and elevated alpha-smooth muscle actin (alpha-SMA) expression. Most PS-NPs were accumulated in non-parenchymal liver cells, with Kupffer cells exhibiting the highest uptake. This accumulation was associated with enhanced recruitment of CD68-positive macrophages. However, PS-NPs were not associated with TGF-beta expression in CD68-positive cells. Additionally, CD68-positive cells treated with PS-NPs did not affect alpha-SMA expression in HSCs. Further in vitro experiments revealed that alpha-SMA and pSmad2/3 were directly promoted by PS-NPs in both LX-2 HSCs and primary isolated HSCs, indicating a direct stimulatory effect on HSC activation. PS-NPs enhanced pTGFBR1 expression of HSCs by promoting stretch-induced mechanical stress, suggesting a novel pathway through which nanoplastics may exacerbate fibrogenesis. Our findings provide the first evidence that PS-NPs, as xenobiotic particles, can directly promote HSC activation and exacerbate liver fibrosis, indicating potential health risks associated with chronic nanoplastic exposure. 2025-12-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60470 Title: Bioreducible Cu2O cluster-glutathione nanohybrids with multienzyme-mimetic ROS scavenging for cisplatin-induced acute kidney injury Author(s): Lee, Hokyung; Noh, Dahye; Lee, Kyeong-Min; Ahn, Young; Park, Shin Young; Shin, Jiyeon; Shim, Man Kyu; Kim, Sun Hwa; Noh, Tae Il; Kim, Hyun-Chul; Lee, Sangmin; Kim, Kwangmeyung; Han, Hwa Seung; Yoon, Hong Yeol Abstract: Cisplatin (Cis)-induced nephrotoxicity remains a major clinical challenge, largely driven by reactive oxygen species (ROS)-mediated oxidative stress leading to acute kidney injury (AKI). Because effective therapies for AKI remain limited, antioxidants capable of scavenging ROS and selectively accumulating in injured kidney tissue are highly desirable. Artificial nanocatalysts have emerged as promising antioxidant therapeutics owing to their advantages over natural enzymes. Here, we developed bioreducible nanohybrids (GCuNPs) composed of copper(I) oxide (Cu2O) nanocatalysts stabilized by glutathione (GSH), synthesized via the reductive reaction of copper ions in the presence of ascorbic acid and GSH. GCuNPs exhibited enhanced broad-spectrum ROS-scavenging capacity and multi-enzyme-like activities in vitro . Following systemic administration in a Cis-induced AKI mouse model, GCuNPs preferentially accumulated in injured kidneys through an impaired glomerular filtration barrier and loosening of proximal tubular tight junctions. Immunofluorescence analysis revealed that GCuNPs significantly reduced the expression of KIM-1, a proximal tubular injury marker, while preserving HO-1 expression, indicating attenuation of tubular damage and preservation of endogenous antioxidant defense. Furthermore, GCuNP treatment significantly reduced serum creatinine and blood urea nitrogen levels, improved survival, and showed no noticeable toxicity. These findings highlight GCuNPs as a promising therapeutic strategy for mitigating Cis-induced nephrotoxicity and potentially other oxidative stress-associated kidney disorders. 2026-05-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60440 Title: 자성-압전 마이크로 로봇 Author(s): 최홍수; 전성웅; 김진영; 김선형 Abstract: 온열 치료와, 전기적 치료 및 세포 치료가 가능한 자성-압전 마이크로 로봇이 개시된다. 자성-압전 마이크로 로봇은, 바디 및 상기 바디 표면에 형성되며 자성 입자와 압전 입자를 포함하고, 외부 자극에 의해서 상기 자성 입자에서 열이 발생하고, 상기 압전 입자에서 전기 자극이 발생하는 자극 발생층을 포함하여 구성 되고, 상기 자성 입자에 의한 온열 치료와 상기 압전 입자에 의한 전기적 치료 중 어느 하나의 치료 또는 두가지 치료가 동시에 수행된다. https://scholar.dgist.ac.kr/handle/20.500.11750/60431 Title: 자기구동시스템 Author(s): 이학준; Latifi Gharamaleki Nader; 최홍수; 김진영 Abstract: 본 개시에 따른 자기구동시스템은 베드; 상기 베드 일측에 설치한 제1자기발생부; 상기 베드 배면에 설치한 제2자기발생부; 상기 제1, 2자기발생부와 연결한 영상장치; 및 상기 제1, 2자기발생부와 상기 영상장치를 제어하는 제어부; 를 포함할 수 있다.