https://scholar.dgist.ac.kr/handle/20.500.11750/13657 2026-04-04T11:17:37Z https://scholar.dgist.ac.kr/handle/20.500.11750/59934 Title: Widefield cortical activity and functional connectivity during motorized locomotion Author(s): Lee, Chang Hak; Lee, Gawon; Song, Hyejin; Lee, Kwang Abstract: The ability to move within a given environment necessitates constant regulation of sensory and motor functions. However, intricacies of sensory-motor integration via intercortical signal correlation remain to be fully elucidated. In this study, we dissociated internally driven cortical dominance from original signals by removing the influence of behavior variables during locomotion on motorized treadmill, wheel, and disk. There were no significant differences in either original or internally driven activity across the cortex of mice during walking based on the type of track. However, the spatial pattern of internally driven cortical connectivity depended on the track type. Especially, internally driven functional connectivity during sustained locomotion on the treadmill significantly decreased only in the medial M2 regions. Thus, the maintenance of stable locomotion on a linear runway is indicative of successful internal sensory-motor integration, which is achieved through inhibitory control of M2. Our findings demonstrate that the spatial patterns of cortical functional connectivity during locomotion are altered by the gait kinematics following physical rotation of the track. Furthermore, we suggest that understanding of health and disorder related to locomotion in environmental contexts requires the consideration of internally driven activity and functional connectivity across the widefield cortex. https://scholar.dgist.ac.kr/handle/20.500.11750/59929 Title: Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy Author(s): Seo-Jin Oh; Jin-jyeok Jang; Jean-Pierre Roussarie; Gyeong-un Jang; Min-seok Jeong; Yeon Suk Jo; Chang-Hoon Shin; Hongsoo Choi; Kwang Lee; Yoon, Jong-Hyeok; Yong-Seok Oh Abstract: Selective serotonin reuptake inhibitors (SSRIs) exhibit delayed therapeutic effects despite rapid serotonin elevation, suggesting their dependence on slow neuroplastic adaptations. Here, we demonstrate that antidepressant actions require cell type-specific translational regulation of the peptidergic signaling in the dentate gyrus (DG). Chronic, but not acute, treatment with an SSRI fluoxetine (FLX) selectively enhances translational activity in hilar mossy cells (MCs), with no detectable changes in neighboring granule cells (GCs). Combining Translating Ribosome Affinity Purification (TRAP) with RNA sequencing revealed distinct baseline translatomes between these two glutamatergic neurons and identified FLX-induced remodeling of peptidergic pathways in the DG. Crucially, we discovered MC-specific enrichment of the neuropeptide PACAP, which undergoes translation-dependent upregulation by chronic FLX treatment. This PACAP induction mediates neuroadaptive plasticity in PAC1 receptor-expressing GCs and drives behavioral responses prominently in female mice during prolonged FLX administration. Our findings establish cell type-specific translational reprogramming as a novel mechanistic framework for antidepressant action. https://scholar.dgist.ac.kr/handle/20.500.11750/59891 Title: Optical dual brain signal tester Author(s): 김효원; 이민용; 박영권; 이광 Abstract: The present invention relates to an optical fiber photometric measurement technique. An optical brain signal measurement device (100) according to one embodiment may comprise a light source unit (110), an excitation filter unit (120), a first split-splice unit (130), a second split-splice unit (140), an emission filter unit (150), and a measurement unit (160). The optical brain signal measurement device 100 transmits an optical signal to a brain signal measurement object through a directional optical fiber, divides or splices the signal through a dividing and splicing part, and recognizes a wavelength range corresponding to each of the multiple signals through an optical splitter, thereby eliminating a dichroic filter. Therefore, multiple brain signals (multiple light sources) can be obtained by using the light source directivity of the optical fiber and the optical splitter. https://scholar.dgist.ac.kr/handle/20.500.11750/58853 Title: 매크로 형광 현미경 Author(s): 이창학; 이광; 이승민; 김광일 Abstract: 본 발명은 출력단을 통해 해당 파장 대역의 조사광을 조사하는 광원부와, 상기 광원부의 출력단에 일측편이 연결되고, 내부에는 상기 광원부를 통해 인입된 조사광의 진행 방향을 변환시키고, 피사체에서 발현된 해당 파장 대역의 형광을 통과시키는 케이지 큐브와, 상기 케이지 큐브의 하측편에 연결되고, 피사체에 조사된 조사광과 형광 단백질의 반응하여 발현된 형광으로 이미지 상이 생성되도록 초점을 맞추는 제1마운트렌즈와, 상기 케이지 큐브의 상측편에 연결되어, 상기 제1마운트렌즈와 수직선상으로 배치되고, 상기 제1마운트렌즈에 의해 생성된 이미지 상을 확대하여 초점을 맞추는 제2마운트렌즈, 및 상기 제2마운트렌즈와 연결되고, 상기 제2마운트렌즈에 의해 생성된 형광에 따른 피사체의 이미지를 촬영하는 씨모스 이미지센서;를 포함하여, 화각이 12 ~ 200mm 중 어느 하나의 화각이 선택되고, 조리개값이 f0.95 ~ F32 중 어느 하나의 조리개값이 선택되는 마운트렌즈를 대물렌즈와 접안렌즈로 사용함으로써, 심도(Depth of Field, DOF)를 종래보다 향상시켜, 넓은 범위에서 피사체(동물의 피질 전체)의 표면을 이미징 할 때, 피사체의 굴곡진 가장자리 부분까지 동일한 초점이 적용되기에, 종래보다 광범위한 고화질 이미지를 초고속으로 기록할 수 있고, 한 번의 이미징을 통해 대면적에서 수많은 신경세포의 활성을 동시에 기록할 수 있어, 서로 다른 영역을 시차 없이 동영상으로 기록할 수 있는 매크로 형광 현미경을 제공한다.