https://scholar.dgist.ac.kr/handle/20.500.11750/16864 2026-08-19T22:09:17Z https://scholar.dgist.ac.kr/handle/20.500.11750/60570 Title: Gpr151 유전자의 5'UTR 또는 이의 변이체를 이용한 신경 손상의 치료 Author(s): 이진영; 조용철; 전예원; 이봄; 신정은 Abstract: Disclosed is a composition for treating a neurological disease caused by nerve injury, including an isolated polynucleotide of a 5′-untranslated region (5′UTR) of a Gpr151 gene or a variant thereof. Also disclosed are a novel variant polynucleotide of 5′UTR of a Gpr151 gene and a vector including the polynucleo https://scholar.dgist.ac.kr/handle/20.500.11750/60411 Title: CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons Author(s): Jin, Hoyong; Jang, Eunsu; Park, Eunhye; Lee, Ju Yeon; Song, Ju Hwan; Cho, Yongcheol Abstract: Mitochondrial proteostasis in neurons relies on the coordinated expression, targeting, and import of a predominantly nuclear-encoded proteome to meet high metabolic demands. Here, we identify the RNA-binding protein cold shock domain containing E1 (CSDE1) as a TOM20-associated factor linked to mitochondrial protein-encoding mRNAs in sensory neurons. CSDE1 immunoprecipitation followed by sequencing from na & iuml;ve dorsal root ganglion tissue revealed association with nuclear-encoded mitochondrial mRNAs enriched for inner membrane/matrix and oxidative phosphorylation pathways. A subset of CSDE1 localized to mitochondria and associated with the outer mitochondrial membrane import receptor TOM20 via its N-terminal region in an RNA-independent manner. In cultured sensory neurons, CSDE1 depletion reduced the mitochondrial-fraction abundance of representative nuclear-encoded electron transport chain mRNAs and decreased the abundance of selected mitochondrial proteins in the mitochondrial fraction. CSDE1 depletion reduced TMRM-positive mitochondrial puncta density along sensory neurites, without significantly increasing MitoSOX-detectable mitochondrial superoxide signals under either basal or oxidative challenge conditions. These findings identify CSDE1 as a TOM20-associated RNA-binding protein linked to mitochondrial protein-encoding transcripts in sensory neurons and support a model in which CSDE1 contributes to mitochondria-associated post-transcriptional regulation. 2026-04-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58813 Title: TREATMENT OF NERVE DAMAGE USING 5`UTR OF GPR151 GENE OR VARIANT THEREOF Author(s): 이진영; 신정은; 전예원; 이봄; 조용철 Abstract: Disclosed is a composition for treating neurological diseases caused by nerve damage comprising an isolated polynucleotide of 5'UTR (untranslated region) of Gpr151 gene or a variant thereof. Also, disclosed are novel variant polynucleotides of 5'UTR of Gpr151 gene, and vectors comprising the polynucleotides. https://scholar.dgist.ac.kr/handle/20.500.11750/57674 Title: Gpr151 유전자의 5'UTR 또는 이의 변이체를 이용한 신경 손상의 치료 Author(s): 전예원; 이진영; 조용철; 이봄; 신정은 Abstract: Gpr151 유전자의 5'UTR (untranslated region)의 단리된 폴리뉴클레오티드 또는 이의 변이체를 포함하는 신경 손상에 의한 신경질환 치료용 조성물이 개시된다. 또한, Gpr151 유전자의 5'UTR 의 신규한 변이체 폴리뉴클레오티드, 및 상기 폴리뉴클레오티드를 포함하는 벡터가 개시된다.