https://scholar.dgist.ac.kr/handle/20.500.11750/16864 2026-06-16T04:05:47Z https://scholar.dgist.ac.kr/handle/20.500.11750/60411 Title: CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons Author(s): Jin, Hoyong; Jang, Eunsu; Park, Eunhye; Lee, Ju Yeon; Song, Ju Hwan; Cho, Yongcheol Abstract: Mitochondrial proteostasis in neurons relies on the coordinated expression, targeting, and import of a predominantly nuclear-encoded proteome to meet high metabolic demands. Here, we identify the RNA-binding protein cold shock domain containing E1 (CSDE1) as a TOM20-associated factor linked to mitochondrial protein-encoding mRNAs in sensory neurons. CSDE1 immunoprecipitation followed by sequencing from na & iuml;ve dorsal root ganglion tissue revealed association with nuclear-encoded mitochondrial mRNAs enriched for inner membrane/matrix and oxidative phosphorylation pathways. A subset of CSDE1 localized to mitochondria and associated with the outer mitochondrial membrane import receptor TOM20 via its N-terminal region in an RNA-independent manner. In cultured sensory neurons, CSDE1 depletion reduced the mitochondrial-fraction abundance of representative nuclear-encoded electron transport chain mRNAs and decreased the abundance of selected mitochondrial proteins in the mitochondrial fraction. CSDE1 depletion reduced TMRM-positive mitochondrial puncta density along sensory neurites, without significantly increasing MitoSOX-detectable mitochondrial superoxide signals under either basal or oxidative challenge conditions. These findings identify CSDE1 as a TOM20-associated RNA-binding protein linked to mitochondrial protein-encoding transcripts in sensory neurons and support a model in which CSDE1 contributes to mitochondria-associated post-transcriptional regulation. 2026-04-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58813 Title: TREATMENT OF NERVE DAMAGE USING 5`UTR OF GPR151 GENE OR VARIANT THEREOF Author(s): 이진영; 신정은; 전예원; 이봄; 조용철 Abstract: Disclosed is a composition for treating neurological diseases caused by nerve damage comprising an isolated polynucleotide of 5'UTR (untranslated region) of Gpr151 gene or a variant thereof. Also, disclosed are novel variant polynucleotides of 5'UTR of Gpr151 gene, and vectors comprising the polynucleotides. https://scholar.dgist.ac.kr/handle/20.500.11750/57674 Title: Gpr151 유전자의 5'UTR 또는 이의 변이체를 이용한 신경 손상의 치료 Author(s): 전예원; 이진영; 조용철; 이봄; 신정은 Abstract: Gpr151 유전자의 5'UTR (untranslated region)의 단리된 폴리뉴클레오티드 또는 이의 변이체를 포함하는 신경 손상에 의한 신경질환 치료용 조성물이 개시된다. 또한, Gpr151 유전자의 5'UTR 의 신규한 변이체 폴리뉴클레오티드, 및 상기 폴리뉴클레오티드를 포함하는 벡터가 개시된다. https://scholar.dgist.ac.kr/handle/20.500.11750/57301 Title: Dipeptidyl peptidase 4 as an injury-responsive protein in the mouse sciatic nerve Author(s): Oh, Yeonsoo; Cho, Yongcheol Abstract: Dipeptidyl peptidase 4 (DPP4) is a membrane-bound protease known for its roles in immunity and metabolism; however, its function in the nervous system remains largely unexplored. We found that DPP4 is predominantly expressed in the Schwann cells of the sciatic nerve, and its systemic depletion in postnatal mice resulted in a decline in motor function. Importantly, the inhibition of its proteolytic activity did not affect axon regeneration, indicating that DPP4′s protease activity may not be directly involved in axon regeneration. Instead, we observed a reduction in DPP4 protein levels in the sciatic nerve after injury and increased in serum postinjury, suggesting that DPP4 may be shed into circulation, potentially mediating systemic responses following injury. These findings highlight DPP4′s importance in sensory function and its potential role in systemic responses after peripheral nerve injury. © 2024 The Author(s) 2024-11-30T15:00:00Z