https://scholar.dgist.ac.kr/handle/20.500.11750/16864 2026-04-16T15:02:13Z https://scholar.dgist.ac.kr/handle/20.500.11750/58813 Title: TREATMENT OF NERVE DAMAGE USING 5`UTR OF GPR151 GENE OR VARIANT THEREOF Author(s): 이진영; 신정은; 전예원; 이봄; 조용철 Abstract: Disclosed is a composition for treating neurological diseases caused by nerve damage comprising an isolated polynucleotide of 5'UTR (untranslated region) of Gpr151 gene or a variant thereof. Also, disclosed are novel variant polynucleotides of 5'UTR of Gpr151 gene, and vectors comprising the polynucleotides. https://scholar.dgist.ac.kr/handle/20.500.11750/57674 Title: Gpr151 유전자의 5'UTR 또는 이의 변이체를 이용한 신경 손상의 치료 Author(s): 전예원; 이진영; 조용철; 이봄; 신정은 Abstract: Gpr151 유전자의 5'UTR (untranslated region)의 단리된 폴리뉴클레오티드 또는 이의 변이체를 포함하는 신경 손상에 의한 신경질환 치료용 조성물이 개시된다. 또한, Gpr151 유전자의 5'UTR 의 신규한 변이체 폴리뉴클레오티드, 및 상기 폴리뉴클레오티드를 포함하는 벡터가 개시된다. https://scholar.dgist.ac.kr/handle/20.500.11750/57301 Title: Dipeptidyl peptidase 4 as an injury-responsive protein in the mouse sciatic nerve Author(s): Oh, Yeonsoo; Cho, Yongcheol Abstract: Dipeptidyl peptidase 4 (DPP4) is a membrane-bound protease known for its roles in immunity and metabolism; however, its function in the nervous system remains largely unexplored. We found that DPP4 is predominantly expressed in the Schwann cells of the sciatic nerve, and its systemic depletion in postnatal mice resulted in a decline in motor function. Importantly, the inhibition of its proteolytic activity did not affect axon regeneration, indicating that DPP4′s protease activity may not be directly involved in axon regeneration. Instead, we observed a reduction in DPP4 protein levels in the sciatic nerve after injury and increased in serum postinjury, suggesting that DPP4 may be shed into circulation, potentially mediating systemic responses following injury. These findings highlight DPP4′s importance in sensory function and its potential role in systemic responses after peripheral nerve injury. © 2024 The Author(s) 2024-11-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/47691 Title: βPix Guanine Nucleotide Exchange Factor Regulates Regeneration of Injured Peripheral Axons Author(s): Jeon, Yewon; Shin, Yoon Kyung; Kim, Hwigyeong; Choi, Yun Young; Kang, Minjae; Kwon, Younghee; Cho, Yongcheol; Chi, Sung Wook; Shin, Jung Eun Abstract: Axon regeneration is essential for successful recovery after peripheral nerve injury. Although growth cone reformation and axonal extension are crucial steps in axonal regeneration, the regulatory mechanisms underlying these dynamic processes are poorly understood. Here, we identify βPix (Arhgef7), the guanine nucleotide exchange factor for Rac1 GTPase, as a regulator of axonal regeneration. After sciatic nerve injury in mice, the expression levels of βPix increase significantly in nerve segments containing regenerating axons. In regrowing axons, βPix is localized in the peripheral domain of the growth cone. Using βPix neuronal isoform knockout (NIKO) mice in which the neuronal isoforms of βPix are specifically removed, we demonstrate that βPix promotes neurite outgrowth in cultured dorsal root ganglion neurons and in vivo axon regeneration after sciatic nerve crush injury. Activation of cJun and STAT3 in the cell bodies is not affected in βPix NIKO mice, supporting the local action of βPix in regenerating axons. Finally, inhibiting Src, a kinase previously identified as an activator of the βPix neuronal isoform, causes axon outgrowth defects in vitro, like those found in the βPix NIKO neurons. Altogether, these data indicate that βPix plays an important role in axonal regrowth during peripheral nerve regeneration. © 2023 by the authors. 2023-08-31T15:00:00Z