https://scholar.dgist.ac.kr/handle/20.500.11750/171 2026-08-23T22:23:02Z https://scholar.dgist.ac.kr/handle/20.500.11750/60611 Title: 96-Well Format-Based Liver–Heart-on-a-Chip Platform for Facile and Parallel Testing of Drug-Induced Cardiotoxicity after Liver Metabolism Author(s): Lee, Sebeen; Jin, Chaewon; Choi, Hongsoo; Kim, Jin-young Abstract: Current preclinical drug evaluation predominantly relies on conventional two-dimensional (2D) cell cultures grown in static environments, which lack dynamic interactions and fail to recapitulate complex microenvironments. These approaches are inefficient and overly simplistic, and often require costly animal models that poorly mimic human physiology. Body-on-a-chip (BoC) technology─comprising robust and flexible three-dimensional (3D) microtissues (MTs)─has emerged to address these limitations. BoC platforms constitute microphysiological systems that mimic human organ physiology and function in vitro, enabling improved toxicity screening and personalized medicine. Here, we present a 96–well format-based microfluidic liver–heart-on-a-chip platform that supports parallel, gravity-driven perfusion to efficiently predict and assess multiorgan drug effects. We demonstrate hepatic metabolism of the cardiotoxic prodrug terfenadine (TFND) into its noncardiotoxic metabolite fexofenadine within liver MTs and the consequent physiological–pathological responses of cardiac MTs. The optimized liver–heart-on-a-chip preserves multitissue functionality, underscores the importance of continuous media circulation, and reveals intertissue interactions relevant to drug-induced cardiotoxicity after liver metabolism. 2026-02-28T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60440 Title: 자성-압전 마이크로 로봇 Author(s): 최홍수; 전성웅; 김진영; 김선형 Abstract: 온열 치료와, 전기적 치료 및 세포 치료가 가능한 자성-압전 마이크로 로봇이 개시된다. 자성-압전 마이크로 로봇은, 바디 및 상기 바디 표면에 형성되며 자성 입자와 압전 입자를 포함하고, 외부 자극에 의해서 상기 자성 입자에서 열이 발생하고, 상기 압전 입자에서 전기 자극이 발생하는 자극 발생층을 포함하여 구성 되고, 상기 자성 입자에 의한 온열 치료와 상기 압전 입자에 의한 전기적 치료 중 어느 하나의 치료 또는 두가지 치료가 동시에 수행된다. https://scholar.dgist.ac.kr/handle/20.500.11750/60431 Title: 자기구동시스템 Author(s): 이학준; Latifi Gharamaleki Nader; 최홍수; 김진영 Abstract: 본 개시에 따른 자기구동시스템은 베드; 상기 베드 일측에 설치한 제1자기발생부; 상기 베드 배면에 설치한 제2자기발생부; 상기 제1, 2자기발생부와 연결한 영상장치; 및 상기 제1, 2자기발생부와 상기 영상장치를 제어하는 제어부; 를 포함할 수 있다. https://scholar.dgist.ac.kr/handle/20.500.11750/60229 Title: A magnetically steerable soft gripper for navigating and grasping in constrained spaces Author(s): Dong Xiao; Lee, Hakjoon; Ahmed, Awais; Choi, Hongsoo Abstract: Magnetic soft grippers hold significant promise for applications requiring gentle and soft interaction with objects. However, steering their movement within constrained spaces remains a major challenge. This study presents a magnetically steerable soft gripper that combines a magnetically steerable soft tube with a magnetic soft gripper. By utilizing distinct magnetization directions for the soft gripper and soft tube, both steering and gripping can be achieved through an external magnetic field. The gripper is capable of lifting objects weighing more than 68 times its own weight under a 40 mT magnetic field (1.7 times per mT). It can also grasp objects of various shapes and sizes. When integrated with a commercial catheter, the steerable gripper successfully performs targeted gripping in a 3D phantom environment. This work introduces a novel magnetically steerable soft gripper system for precise manipulation in confined spaces, with strong potential for applications inside the human body. © The Korean Society of Mechanical Engineers and Springer-Verlag GmbH Germany, part of Springer Nature 2026. 2025-12-31T15:00:00Z