https://scholar.dgist.ac.kr/handle/20.500.11750/265 2026-07-26T14:15:28Z https://scholar.dgist.ac.kr/handle/20.500.11750/60475 Title: Broadband Circularly Polarized Light Detection via Spin-Selective Charge Transport in Quantum Dot Photodiodes Author(s): Kim, Minseo; Li, Shi; Lee, Kyunghoon; Ahn, Eonhyoung; Lee, Soyeon; Kim, Kiwook; Kim, Hang; Yu, Wookyung; Choi, Changsoon; Lim, Jung Ah; Hwang, Jeeseong; Kim, Dae-Hyeong; Yang, Jiwoong Abstract: Circularly polarized light (CPL) detection provides polarization-resolved information, enabling advanced applications in quantum technologies, bioimaging, secure communications, and multi-level optical data processing. However, conventional CPL photodetectors typically rely on intrinsically chiral absorbers, restricting operation to the UV-vis range and hindering extension into the near-infrared (NIR) and shortwave infrared (SWIR), which are critical for deep tissue imaging and low-visibility sensing. Here, we demonstrate broadband CPL detection with quantum dot (QD) photodiodes that exploit the chiral-induced spin selectivity effect in chiral-ZnO charge transport layers. Chiral ligand-functionalized ZnO electron transport layers selectively transmit spin-polarized charge carriers from QDs, enabling CPL-specific photocurrent generation even in spectral regions without intrinsic chiral absorption. Heavy-metal-free Cu-In-Se QD-photodiodes exhibit outstanding specific detectivity (D *) of 1.28 x 1012 Jones without external bias and broadband CPL detection (g Iph: similar to 0.17 at 260 nm and similar to 0.13 at 780 nm), while PbS QD-devices extend CPL detection across 250-1700 nm (UV-Vis-NIR-SWIR) with superior performance (D *: 1.45 x 1012 Jones). The chiral-transport-driven strategy offers fundamental insights into CPL photodetection and establishes a scalable and optically passive platform for broadband polarization-resolved optoelectronics. 2026-02-28T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60465 Title: Multi-scale imaging and recording of in-vivo neural activity Author(s): Lee, Min Yong; Kim, Hyo Won; Lee, Kwang Abstract: Most in vivo neural technologies have been developed to enhance the resolution of subcellular neuronal activity or to expand the spatial range for tracking ensembles of neurons in the brains of live animals. While these approaches offer great promise for understanding cellular and circuit functions in behaving mammals, their cross-sectional observations are inherently limited in accounting for causal interactions of neural dynamics across various scales of brain architecture. Consequently, the simultaneous observation of multi-scale neural activity has emerged as a crucial strategy for achieving a more comprehensive understanding of brain function. These advancements facilitate the simultaneous detection of diverse signals, providing unprecedented insights into dynamic neurophysiological mechanisms within three-dimensional brain structures that remain poorly understood. Here, we review state-of-the-art technologies for the parallel observation of multiple neural targets in vivo. We highlight strategies for simultaneously observing brain signals at multiple resolutions, aiming to bridge the spatiotemporal gaps between microscopic and macroscopic domains of neurobiology. We also emphasize the technical integration of neural tools to concurrently acquire electrophysiological activity and optical imaging, leveraging their complementary strengths. Finally, we discuss the future challenges and potential prospects of multimodal neural techniques, paving the way for a deeper understanding of brain functions and disorders. [BMB Reports 2026; 59(2): 124-136] 2026-01-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60414 Title: Shared and Divergent Transcriptional Programs of Oligodendrocyte Differentiation Across Vertebrate Species Revealed by scRNA-seq Analysis Author(s): Yun, Tery; Park, Junhee; Baek, Myungin Abstract: A myelination is essential for neural function in the vertebrate central nervous system, yet the molecular details of how the oligodendrocyte differentiation program has evolved remain poorly understood. Here, we performed a cross-species single-cell transcriptomic analysis of oligodendrocyte lineage cells in the spinal cord of five vertebrate species: fugu, mudskipper, chicken, mouse, and human. Pseudotime trajectory analysis revealed a shared oligodendrocyte progenitor cell (OPC) to committed oligodendrocyte precursor (COP) to myelin-forming oligodendrocyte (MOL) differentiation trajectory across all species, and CAME-based cross-species mapping confirmed the homology of OPC and MOL identities, while COP showed reduced mapping in teleosts compared with amniotes. Among stage-specific DEGs, highly shared genes (≥4 species) were organized into four co-expression modules encompassing cell projection organization, myelination, synapse assembly, and ribonucleoprotein biogenesis, with evolutionary core genes (all 5 species) enriched for oligodendrocyte differentiation and Wnt signaling. Strikingly, amniote-exclusive genes were enriched for synaptic vesicle transport, cell projection organization, predominantly at the OPC stage. This asymmetry indicates that amniotes have expanded the oligodendrocyte differentiation program at the progenitor stage, potentially linked to the myelination demands of terrestrial locomotor circuits. Our findings provide insights into how the oligodendrocyte differentiation program has been shaped by both deep evolutionary conservation and lineage-specific adaptation. 2026-04-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60411 Title: CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons Author(s): Jin, Hoyong; Jang, Eunsu; Park, Eunhye; Lee, Ju Yeon; Song, Ju Hwan; Cho, Yongcheol Abstract: Mitochondrial proteostasis in neurons relies on the coordinated expression, targeting, and import of a predominantly nuclear-encoded proteome to meet high metabolic demands. Here, we identify the RNA-binding protein cold shock domain containing E1 (CSDE1) as a TOM20-associated factor linked to mitochondrial protein-encoding mRNAs in sensory neurons. CSDE1 immunoprecipitation followed by sequencing from na & iuml;ve dorsal root ganglion tissue revealed association with nuclear-encoded mitochondrial mRNAs enriched for inner membrane/matrix and oxidative phosphorylation pathways. A subset of CSDE1 localized to mitochondria and associated with the outer mitochondrial membrane import receptor TOM20 via its N-terminal region in an RNA-independent manner. In cultured sensory neurons, CSDE1 depletion reduced the mitochondrial-fraction abundance of representative nuclear-encoded electron transport chain mRNAs and decreased the abundance of selected mitochondrial proteins in the mitochondrial fraction. CSDE1 depletion reduced TMRM-positive mitochondrial puncta density along sensory neurites, without significantly increasing MitoSOX-detectable mitochondrial superoxide signals under either basal or oxidative challenge conditions. These findings identify CSDE1 as a TOM20-associated RNA-binding protein linked to mitochondrial protein-encoding transcripts in sensory neurons and support a model in which CSDE1 contributes to mitochondria-associated post-transcriptional regulation. 2026-04-30T15:00:00Z