https://scholar.dgist.ac.kr/handle/20.500.11750/27 2026-06-11T00:09:33Z https://scholar.dgist.ac.kr/handle/20.500.11750/60389 Title: Histone modification cross-talk: analytical tools and molecular mechanisms Author(s): Jiang, Jennifer; DuBois-Coyne, Sarah; Nam, Eunju; Whedon, Samuel D.; Lee, Kwangwoon; Cole, Philip A. Abstract: Chromatin function emerges from combinatorial patterns of histone post-translational modifications (PTMs) that are read, written, and erased by dedicated enzymes. Over the past 30years, increasing evidence suggests that specific histone PTMs or combinations of PTMs influence one another, constituting epigenetic cross-talk that shapes chromatin structure, protein-protein interactions, and catalytic efficiency of nucleosome-targeting enzymes. Here, we summarize mechanistic and methodological advances that enable rigorous interrogation of histone PTM interplay. We highlight selected nucleosome engineering strategies that build precisely modified substrates to test in vitro, proteomic pipelines that preserve combinatorial information, and omics technology that can globally profile integrated chromatin regulatory events in cells and tissues. Furthermore, we survey multivalent reader modules and engineered biosensors that report combinatorial marks in nucleosomes and living cells. Representative case studies illustrate how defined PTMs modulate catalytic parameters of writer and eraser complexes, including lysine methyltransferases, demethylases, acetyltransferases, and deacetylases, focusing on cross-talk with histone H3 N-terminal tail marks. These include the role of H3K9me2/3 and K14ac in directing propagation of H3K9me3, the role of H3K4me1/2 and K14ac in slowing H3K4 demethylation, the role of H3K4me2/3 in directing H3K9 acetylation, and the role of H3K36 methylation in directing deacetylation of H3 and H4. The substrates for these case studies include both mononucleosomes and nucleosome arrays. These examples illustrate the principle of epigenetic cross-talk, namely, that specific combinatorial PTMs can affect enzymes and alter local biochemistry. 2026-04-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60375 Title: 사파이어 미스컷 기판을 이용한 무자기장 스핀궤도토크 스위칭 소자 Author(s): 김진아; 유천열; 안수혁 https://scholar.dgist.ac.kr/handle/20.500.11750/60366 Title: Spectroscopic Evidence of a Reduced Alkenylnickel Intermediate in Catalytic Markovnikov-Selective Alkyne Hydroboration Author(s): Lee, Jeong Woo; Kim, Gun Ha; Jeong, Seo Yeong; Jeon, Ji Hwan; Kwon, Hyejin; Kim, Yung Sam; Jung, Byunghyuck; Seo, Sangwon; Rohde, Jan-Uwe; Hong, Sung You Abstract: Nickel-catalyzed hydrofunctionalization reactions, including the hydroboration of alkynes, have been generally proposed to proceed via classical two-electron pathways or, alternatively, through a NiIH-based insertion mechanism. Despite efforts to discern these pathways, explicit spectroscopic observation of NiIH species and relevant mechanistic information on LNiI(alkenyl) species remain lacking. Herein, we provide experimental evidence of formal NiI intermediates, suggestive of a NiIH-based insertion mechanism for alkyne hydroboration. The formation of a NiI catalyst precursor, LnNiI(dpm) (dpm = dipivaloylmethanate anion) and an LnNi(alkenyl) intermediate was confirmed by EPR spectroscopy and HRMS analysis. Their involvement in the catalytic reaction was demonstrated by stoichiometric and catalytic reactivity studies. The origin of the counterintuitive Markovnikov selectivity in the formation of the α-alkenylboronate product was probed by systematic ligand electronic effect studies. Computational analyses rationalize the selectivity by a kinetic preference for formation of the α regioisomer of the LnNi(alkenyl) intermediate through noncovalent interactions. 2026-03-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/60364 Title: Cosolvent-Modulated Donor Preaggregation Enhances Molecular Order in 20% Efficient Bilayer Organic Solar Cells Author(s): Pang, Wei; Chung, Sein; Zhong, Jiancheng; Chen, Guanlin; Wei, Wuning; Zhang, Guangquan; Cao, Chenxi; Qin, Yuanyuan; Tang, Hua; Huang, Silu; Liang, Anhai; Tan, Lixing; Bai, Liang; Cho, Yongjoon; Zhu, Chaofeng; Cho, Kilwon; Zhao, Zhenmin; Kan, Zhipeng Abstract: Solvent selection critically modulates the aggregation behavior within the active layer, ultimately determining the performance of bilayer organic solar cells (OSCs). However, good solvents (e.g., chloroform and chlorobenzene) for polymer donors typically exhibit moderate boiling points, which suppress rapid aggregation, resulting in a smaller aggregate size and ultimately affecting charge transport properties. Herein, we demonstrate that trace DCM addition to CF modulates donor preaggregation, which enables precise fiber size control, increases the crystallinity, and enhances molecular ordering, thereby facilitating efficient charge transport. Therefore, bilayer OSCs processed with a cosolvent based on CF and DCM suppress bimolecular recombination, reduce trap density, extend carrier lifetime, and enhance carrier mobility, thereby improving charge extraction efficiency, achieving a notable 20.0% efficiency, and establishing it as one of the most efficient binary bilayer OSCs reported to date. The present strategy sheds light on manipulating donor preaggregation states to achieve superior molecular organization, laying the groundwork for advancing bilayer OSC performance. 2026-04-30T15:00:00Z