https://scholar.dgist.ac.kr/handle/20.500.11750/271 2026-04-16T16:32:06Z https://scholar.dgist.ac.kr/handle/20.500.11750/9613 Title: Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway Author(s): Kim, Sung-Eun; Ko, Il-Gyu; Ji, Eun-Sang; Jin, Jun-Jang; Hwang, Lakkyong; Kim, Sang-Hoon; Cho, Sehyung; Kim, Chang-Ju; Kim, Kyungjin; Kim, Khae Hawn Abstract: Purpose: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. Methods: BMAL1 knockdown transgenic mice (BMAL1 TG) were used as the BMAL1-TG group and the BMAL1-TG with treadmill exercise group. Female C57BL/6J mice of the same age were used as the wildtype group and the wildtype with treadmill exercise group. The mice in the treadmill exercise groups performed running on a motorized treadmill under the dark-dark conditions for 8 weeks. Short-term memory, nonspatial object memory, and spatial learning memory were determined using step-down avoidance test, novel object-recognition test, and radial 8-arm maze test. Immunohistochemistry for doublecortin and 5-bromo-2'-deoxyuridine was conducted for the determination of hippocampal neurogenesis. Using the western blot analysis, we determined the expressions of glucocorticoid receptor (GR) and factors related to the neurogenesis and memory consolidation, such as brain-derived neurotrophic factor, tyrosine kinase B, p44/42 mitogen-activated protein kinase, cyclic AMP-responsive element binding protein, phosphatidylinositol 3-kinase, protein kinas B, protein kinase C alpha, early-growth-response gene 1. Results: Circadian rhythm disruption impaired memory function through inhibiting the expressions of GR and the factors related to neurogenesis and memory consolidation. Treadmill exercise improved memory function via enhancing the expressions of GR and above-mentioned factors. Conclusions: Treadmill exercise acts as the zeitgeber that improves memory function under the circadian rhythm disrupted conditions. © 2019 Korean Continence Society 2019-01-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/9579 Title: Korea Brain Initiative: Emerging Issues and Institutionalization of Neuroethics Author(s): Jeong, Sung-Jin; Lee, In Young; Jun, Bang Ook; Ryu, Young-Joon; Sohn, Jeong-woo; Kim, Sung-Phil; Woo, Choong-Wan; Koo, Ja Wook; Cho, Il-Joo; Oh, Uhtaek; Kim, Kyungjin; Suh, Pann-Ghill Abstract: Neuroscience research has become a national priority for the Korean government. Korean scholars have dedicated interest in the societal ramifications of neurotechnologies; neuroethics is an integral component of the Korea Brain Initiative and to the formation of its growing neuroscience community. © 2019 Elsevier Inc. 2019-01-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/2155 Title: Korea Brain Initiative: Integration and Control of Brain Functions Author(s): Jeong, Sung-Jin; Lee, Haejin; Hur, Eun-Mi; Choe, Youngshik; Koo, Ja Wook; Rah, Jong-Cheol; Lee, Kea Joo; Lim, Hyun-Ho; Sun, Woong; Moon, Cheil; Kim, Kyung Jin Abstract: This article introduces the history and the long-term goals of the Korea Brain Initiative, which is centered on deciphering the brain functions and mechanisms that mediate the integration and control of brain functions that underlie decision-making. The goal of this initiative is the mapping of a functional connectome with searchable, multi-dimensional, and information-integrated features. The project also includes the development of novel technologies and neuro-tools for integrated brain mapping. Beyond the scientific goals this grand endeavor will ultimately have socioeconomic ramifications that not only facilitate global collaboration in the neuroscience community, but also develop various brain science-related industrial and medical innovations. 2016-10-31T15:00:00Z