https://scholar.dgist.ac.kr/handle/20.500.11750/281 2026-04-04T13:36:02Z https://scholar.dgist.ac.kr/handle/20.500.11750/59942 Title: Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells Author(s): Hong, Jihyun; An, Hyun-Kyu; Nam, Hyeri; Choi, Jieun; Yu, Seong-Woon Abstract: Chronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear. We previously showed that chronic stress impairs adult hippocampal neurogenesis by triggering autophagic cell death of adult hippocampal neural stem (HCN) cells. Impairment of adult hippocampal neurogenesis is widely observed in the brains of human AD patients and animal models. However, it remains unknown whether stress-induced death of HCN cells is related to the pathogenesis of AD. In this study, we investigated whether the stress hormone, corticosterone (CORT) induces HCN cell death through presenilin 2 (Psen2), a gene associated with familial AD. Using CRISPR/Cas9-based knockout models and in vitro CORT treatment, we found that Psen2 expression is upregulated by CORT and Psen2 deletion prevents CORT-induced death in HCN cells. However, the Psen2 N141I mutation, despite its pathogenicity in AD, did not exacerbate CORT-induced cell death in vitro and hippocampus-dependent behavioral deficits in vivo. These findings indicate that while Psen2 is essential for stress-induced death of HCN cells, the Psen2 N141I mutation alone may not be sufficient to link chronic stress to AD pathogenesis. 2025-11-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58961 Title: Anti-depressant effects of a human telomerase-derived peptide GV1001 in an animal model of chronic restraint stress Author(s): Kim, Dayoung; Lee, Younghwan; Kim, Sangjae; Yu, Seong-Woon Abstract: Depression is a common cause of mental illness in the modern world, and the wide variation in symptoms makes it difficult to develop suitable antidepressants. The commonly used serotonin reuptake inhibitors (SSRIs) cause many side effects, making it imperative to develop alternative treatments. GV1001, a 16-amino acid peptide derived from human telomerase reverse transcriptase, has shown various neuroprotective effects in recent studies. However, its effects on depression were unknown. In this study, we found that the administration of GV1001 rescued cognitive deficits, anxiety-, and depressive-like behaviors in a mouse model of chronic restraint stress (CRS). GV1001 efficiently reduced the increased serum corticosterone level and suppressed activation of the hypothalamic CRH neurons, suggesting the modulation of the hypothalamus-pituitary-adrenal axis. Collectively, our findings provide evidence for a novel antidepressant efficacy of GV1001. 2025-09-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58798 Title: 디다노신을 포함하는 신경염증성 질환 예방 또는 치료용 조성물 Author(s): 유성운; 황서현; 이영환 Abstract: 本発明は、神経炎症性疾患の予防または治療用組成物に関し、よ https://scholar.dgist.ac.kr/handle/20.500.11750/58772 Title: COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY DISEASES, COMPRISING CHLORPROMAZINE Author(s): 유성운; 남혜리; 이영환 Abstract: The present invention relates to a composition for preventing or treating of neuroinflammatory diseases and, more specifically, to uses, of the composition comprising chlorpromazine or a salt thereof, for preventing, alleviating or treating neuroinflammatory diseases.