Repository Community: null https://scholar.dgist.ac.kr/handle/20.500.11750/293 2026-11-15T15:11:45Z A Sulfonamide Intermediate Elicits Therapeutic Effect Against Sepsis by Enhancing Neutrophil Maturation https://scholar.dgist.ac.kr/handle/20.500.11750/60994 Title: A Sulfonamide Intermediate Elicits Therapeutic Effect Against Sepsis by Enhancing Neutrophil Maturation Author(s): Park, Ji Ye; Jeong, Yu Sun; Shin, Myeongsu; Choi, Ji Woo; Shin, Jiwon; Kwon, Leezhi; Lyu, Kanghyun; Jo, Hwangi; Byun, Youngjoo; Koo, JaeHyung; Bae, Yoe-Sik Abstract: Sepsis, a life-threatening condition characterized by systemic inflammation and immune dysregulation, remains a major cause of mortality worldwide. Here, we identify a synthetic sulfonamide intermediate, 1-[5-(2-fluorophenyl)furan-2-yl]-N-(4-methylbenzyl)methanamine (FMM), as a host-directed therapeutic candidate that enhances neutrophil maturation and antimicrobial function via autophagy. In a Pseudomonas aeruginosa-induced sepsis model, FMM administration markedly improved survival and attenuated inflammatory cytokine levels while reducing tissue injury and immune cell apoptosis. Furthermore, FMM promoted bone marrow neutrophil maturation, increased reactive oxygen species generation, and enhanced neutrophil extracellular trap formation. FMM also activated GPCR-mediated G beta gamma-PLC signalling, which triggered intracellular calcium and ERK/p38 phosphorylation. Notably, FMM lacked direct bactericidal activity, suggesting its therapeutic effects are mediated by host immune modulation rather than pathogen targeting. Collectively, these findings demonstrate that FMM exerts potent pharmacological effects on neutrophil function and represents a promising lead compound for developing host-directed immunomodulatory therapies for sepsis. 2026-08-31T15:00:00Z 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 https://scholar.dgist.ac.kr/handle/20.500.11750/60699 Title: 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 Author(s): 최지우; 배외식; 구재형; 정영수; 김지철; 정유선 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 https://scholar.dgist.ac.kr/handle/20.500.11750/60697 Title: 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 Author(s): 구재형; 정영수; 최지우; 김지철; 배외식; 정유선 2-펜틸퓨란을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 조성물 https://scholar.dgist.ac.kr/handle/20.500.11750/59121 Title: 2-펜틸퓨란을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 조성물 Author(s): 구재형