https://scholar.dgist.ac.kr/handle/20.500.11750/293 2026-09-13T08:32:59Z https://scholar.dgist.ac.kr/handle/20.500.11750/60699 Title: 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 Author(s): 최지우; 배외식; 구재형; 정영수; 김지철; 정유선 https://scholar.dgist.ac.kr/handle/20.500.11750/60697 Title: 후각수용체 Olfr164를 제어하는 패혈증 치료용 조성물 Author(s): 구재형; 정영수; 최지우; 김지철; 배외식; 정유선 https://scholar.dgist.ac.kr/handle/20.500.11750/59121 Title: 2-펜틸퓨란을 유효성분으로 함유하는 퇴행성 뇌질환 치료용 조성물 Author(s): 구재형 https://scholar.dgist.ac.kr/handle/20.500.11750/58513 Title: Protein–Protein Interactions of Odorant and G Protein-Coupled Receptors: A BRET Analysis Approach Author(s): Choi, Ji Woo; Koo, JaeHyung Abstract: Odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, are pivotal not only for olfactory detection in the nose but also for various biological functions in extra-nasal tissues. The functional characterization of ORs presents significant challenges, especially due to the difficulty of achieving their surface expression in in vitro systems. Research indicates that interactions between ORs and other receptors, as well as OR multimerization, are crucial for their membrane localization and the modulation of signaling pathways. Utilizing the bioluminescence resonance energy transfer (BRET) assay, a technique for investigating protein–protein interactions, our study quantifies the interactions between ORs and various receptors. This approach provides novel insights into OR molecular dynamics, emphasizing the role of OR multimerization. By exploring into these complexities, our work aims to enhance the understanding of cellular signaling mechanisms and promote the development of innovative therapeutic strategies. © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2025. 2025-03-31T15:00:00Z