https://scholar.dgist.ac.kr/handle/20.500.11750/317 2026-04-24T13:49:31Z https://scholar.dgist.ac.kr/handle/20.500.11750/60221 Title: Odors modulate self face perception and frontal ERP responses Author(s): Yoon, Seongwon; Moon, Sun Ae; Kim, Kwangsu; Bae, Jisub; Lee, Jeewon; Moon, Cheil Abstract: The face is crucial for social interactions, as it conveys various personal characteristics and influences social judgments. Although previous studies have demonstrated that odors can modulate facial perception and evaluation, these investigations largely focused on others’ faces (other-face). The neural mechanisms underlying self-face perception remain less explored. This study examined how odors differing in pleasantness modulate self-face perception and associated neural responses measured via event-related potentials (ERPs). Thirty-one healthy participants (14 women, 17 men) evaluated their self-faces after exposure to a neutral odor (lavender), an unpleasant odor (isovaleric acid), or solvent control (control). Exposure to isovaleric acid, compared with air and lavender, significantly reduced self-face attractiveness and preference ratings. Beyond these behavioral effects, we observed odor-related modulation of ERP amplitude and latency across multiple time windows, and Positive potential (PP) amplitude in the 300–600 ms interval was positively associated with self-face preference and attractiveness. These neural responses correlated with subjective self-evaluations, highlighting a critical period for affective self-assessment influenced by olfactory stimuli. These results suggest that odors modulate self-face perception and frontal ERP responses. Our findings suggest that everyday olfactory environments subtly shape self-perception, underscoring the broader impact of odors on social and psychological functioning. 2025-12-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/59909 Title: Erythropoietin-derived Non-erythropoietic Peptides Conferring Oxidative Stress Resistance to Keratinocytes and Fibroblasts Author(s): Han, Min Ae; Ashim, Janbolat; Ji, Youngheum; Kang, Eunho; Jeong, Minchan; Kim, Sung Jae; Yu, Wookyung; Kim, Jin Hae; Moon, Cheil; Lee, Chang-Hun Abstract: Erythropoietin (EPO) exerts tissue-protective effects; however, its erythropoietic activity limits broader use. Three EPO-derived peptides (ML1-C1/C2/C3) were designed from the C-helix of EPO to remove erythropoietic activity while retaining cell-protective activity. Circular dichroism and nuclear magnetic resonance spectroscopies were used to assess the solution structures of ML1-C1/C2/C3 peptides. The peptide activities for cytoprotection and growth support were assessed using skin-relevant cells, HaCaT cells and 3T3-L1 cells, which proposes an effect on skin epithelial keratinocytes and pre-adipocytic fibroblasts, respectively. Also, an erythroid-precursor cell line, TF-1, was used to evaluate the erythropoietic function of the three peptides. Spectroscopic analyses of ML1-C1/C2/C3 peptides revealed similar secondary structures and different flexibilities between the peptides. While ML1-C1 and ML1-C3 had highly flexible loop-like structures, ML1-C2 had less flexible loop-like structures. Also, their cellular effects vary in a cell type-dependent manner. The EPO-derived peptides can attenuate H2O2-induced loss of viability in HaCaT cells and 3T3-L1 cells. Under low-serum conditions, the three peptides promoted HaCaT proliferation, whereas only ML1-C1 improved 3T3-L1 proliferation. In TF-1 cells, none of the peptides increased cell viability or hemoglobin staining, whereas recombinant human EPO did, indicating the lack of erythropoietic activity of the peptides under experimental conditions. These findings support the potential of EPO-derived peptides as skin-protective agents and motivate future work for skin therapeutics or cosmetic purposes. https://scholar.dgist.ac.kr/handle/20.500.11750/59310 Title: 물리화학적 특성과 인지적 특성 데이터베이스를 기반으로 하는 향료 특성 예측 시스템 Author(s): 문제일; 배지섭 https://scholar.dgist.ac.kr/handle/20.500.11750/59222 Title: Stable olfactory receptor activation across odor complexity Author(s): Kim, Minseok; Lee, Jeongyoon; Park, Inah; Kim, Jihoon; Lee, Keunsoon; So, Jinhyun; Choi, Ji-Woong; Jang, Jae Eun; Kwon, Hyuk-Jun; Moon, Cheil; Choe, Han Kyoung Abstract: Mechanisms underlying single odorant activation of specific olfactory receptors are well understood. However, how the olfactory system processes complex odor mixtures at the receptor level remains unclear. This study examined olfactory receptor activation patterns across odor complexities using phosphoTRAP analysis. For most mixtures, receptor activation patterns closely matched the linear sum of individual component responses. However, distinct receptor sets display non-linear responses unexplained by linear models. Mixture responses were generally located between component responses and often aligned with linear predictions, though some deviations indicated non-linear interactions. Total activated receptors remained relatively constant regardless of odor complexity, suggesting efficient coding that prevented receptor saturation as odorant components increased. These findings provide receptor-level evidence that the olfactory system encodes complex odors primarily through linear integration of receptor activity, with added specificity from non-linear responses in limited receptors, advancing understanding of how the olfactory system normalizes receptor activation in response to natural odors. 2025-10-31T15:00:00Z