https://scholar.dgist.ac.kr/handle/20.500.11750/749 2026-08-11T08:18:36Z https://scholar.dgist.ac.kr/handle/20.500.11750/60579 Title: hPMCA2w/b 유전자가 탑재된 벡터의 우울증 또는 불안 치료 용도 Author(s): 이효상 Abstract: hPMCA2w/b 유전자가 탑재된 벡터의 우울증 또는 불안 치료 용도에 관한 것으로, 본 발명에 따른 벡터 및 hPMCA2w/b 유전자가 도입된 뇌세포는 불안장애 및 우울증의 치료 효능이 우수하다. https://scholar.dgist.ac.kr/handle/20.500.11750/57299 Title: Astrocytic inhibition of lateral septal neurons promotes diverse stress responses Author(s): Seo, Kain; Won, Sanghyun; Lee, Hee-Yoon; Sin, Yeonju; Lee, Sangho; Park, Hyejin; Kim, Yong Geon; Yang, Seo Young; Kim, Dong-Jae; Suk, Kyoungho; Koo, Ja Wook; Baek, Myungin; Choi, Se-Young; Lee, Hyosang Abstract: Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca²⁺ levels in response to aversive sensory and social stimuli in both male and female mice. This astrocytic Ca²⁺ elevation inhibits neighboring LS neurons by reducing excitatory synaptic transmissions through A1R-mediated signaling in both the dorsal (LSd) and intermediate LS (LSi) and enhancing inhibitory synaptic transmission via A2AR-mediated signaling in the LSi. At the same time, astrocytes reduce inhibitory tone on distant LS neurons. In the LSd, astrocytes promote social avoidance and anxiety, as well as increased heart rate in socially stressed male mice. In contrast, astrocytes in the LSi contribute to elevated heart rate and heightened blood corticosterone levels in unstressed male mice. These results suggest that the dynamic interactions between astrocytes and neurons within the LS modulate physiological and behavioral responses to stressful experiences. © The Author(s) 2024. 2024-10-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/15977 Title: The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons Author(s): Lee, Davin; Seo, Jinsoo; Jeong, Hae Chan; Lee, Hyosang; Lee, Sung Bae Abstract: The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their reliability and practicality as an early diagnostic tool remains unclear. In this article, we discuss the use of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage schizophrenia. Furthermore, we review the viability of discovering and applying these biomarkers through the use of cutting-edge technologies such as human induced pluripotent stem cell (iPSC)-derived neurons, brain models, and single-cell level analyses. Copyright © 2021 Lee, Seo, Jeong, Lee and Lee. 2021-10-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/13827 Title: Astrocytic Regulation of Neural Circuits Underlying Behaviors Author(s): Hwang, Sun-Nyoung; Lee, Jae Seung; Seo, Ga In; Lee, Hyosang Abstract: Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels. 2021-01-31T15:00:00Z