https://scholar.dgist.ac.kr/handle/20.500.11750/751 2026-04-10T03:14:51Z https://scholar.dgist.ac.kr/handle/20.500.11750/57299 Title: Astrocytic inhibition of lateral septal neurons promotes diverse stress responses Author(s): Seo, Kain; Won, Sanghyun; Lee, Hee-Yoon; Sin, Yeonju; Lee, Sangho; Park, Hyejin; Kim, Yong Geon; Yang, Seo Young; Kim, Dong-Jae; Suk, Kyoungho; Koo, Ja Wook; Baek, Myungin; Choi, Se-Young; Lee, Hyosang Abstract: Inhibitory neuronal circuits within the lateral septum (LS) play a key role in regulating mood and stress responses. Even though glial cells can modulate these circuits, the impact of astrocytes on LS neural circuits and their functional interactions remains largely unexplored. Here, we demonstrate that astrocytes exhibit increased intracellular Ca²⁺ levels in response to aversive sensory and social stimuli in both male and female mice. This astrocytic Ca²⁺ elevation inhibits neighboring LS neurons by reducing excitatory synaptic transmissions through A1R-mediated signaling in both the dorsal (LSd) and intermediate LS (LSi) and enhancing inhibitory synaptic transmission via A2AR-mediated signaling in the LSi. At the same time, astrocytes reduce inhibitory tone on distant LS neurons. In the LSd, astrocytes promote social avoidance and anxiety, as well as increased heart rate in socially stressed male mice. In contrast, astrocytes in the LSi contribute to elevated heart rate and heightened blood corticosterone levels in unstressed male mice. These results suggest that the dynamic interactions between astrocytes and neurons within the LS modulate physiological and behavioral responses to stressful experiences. © The Author(s) 2024. 2024-10-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/15977 Title: The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons Author(s): Lee, Davin; Seo, Jinsoo; Jeong, Hae Chan; Lee, Hyosang; Lee, Sung Bae Abstract: The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their reliability and practicality as an early diagnostic tool remains unclear. In this article, we discuss the use of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage schizophrenia. Furthermore, we review the viability of discovering and applying these biomarkers through the use of cutting-edge technologies such as human induced pluripotent stem cell (iPSC)-derived neurons, brain models, and single-cell level analyses. Copyright © 2021 Lee, Seo, Jeong, Lee and Lee. 2021-10-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/13827 Title: Astrocytic Regulation of Neural Circuits Underlying Behaviors Author(s): Hwang, Sun-Nyoung; Lee, Jae Seung; Seo, Ga In; Lee, Hyosang Abstract: Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels. 2021-01-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/10991 Title: Risks of suicide attempts after prescription of zolpidem in people with depression: A nationwide population study in South Korea Author(s): Kim, Hyewon; Kim, Yuwon; Myung, Woojae; Fava, Maurizio; Mischoulon, David; Lee, Unjoo; Lee, Hyosang; Na, Eun Jin; Choi, Kwan Woo; Shin, Myung-Hee; Jeon, Hong Jin Abstract: OBJECTIVES: To investigate the association between zolpidem prescription and suicide attempts in people with depression. METHODS: A nationwide, population-based electronic medical records database from the Health Insurance Review & Assessment Service of South was used to investigate the incidence rate ratios (IRRs) of suicide attempts and probable suicide attempts in people with depression before and after zolpidem prescription using self-controlled case series design. RESULTS: In a total of 445 people who attempted suicide and 23 141 people who attempted probable suicide attempt, the IRRs of suicidal behavior during the risk periods before and after zolpidem prescription increased compared with those at the baseline. The IRRs gradually increased and peaked immediately before the prescription of zolpidem. The IRR was 70.06 (95% CI: 25.58-191.90) on day 2 before zolpidem prescription and 63.35 (95% CI: 22.99-174.59) on day 1 after zolpidem prescription in the suicide attempt group. The IRR was 24.07 (95% CI: 20.50-28.26) on the day before zolpidem prescription and 14.96 (95% CI: 12.21-18.34) on the day after zolpidem prescription in the probable suicide attempt group. The ratios declined eventually after zolpidem was prescribed. CONCLUSIONS: Although zolpidem prescription was associated with an increased risk of suicide attempts in people with depression, the risk increased and peaked immediately before zolpidem prescription. The risk declined gradually thereafter. This result indicates that the risk of suicide attempts increases at the time of zolpidem prescription. However, zolpidem prescription does not contribute to additional increase in the risk of suicide attempts. © Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com. 2020-02-29T15:00:00Z