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시간 인지 행동 학습 훈련 또는 측정을 위한 자동화 시스템

Title: 시간 인지 행동 학습 훈련 또는 측정을 위한 자동화 시스템 Author(s): 김윤경; 최한경 Abstract: 본 발명은 사람의 개입 없이 실험동물이 자발적으로 생활케이지 내에서 시간 인지 실험 및 시간 인지 행동 학습이 수행가능한 자동화 시간 인지 행동 학습 장비를 제공한다. 또한, 본 발명은 상기 시간 인지 행동 학습 장비를 통해 일주기 생체리듬이 정상적으로 작동하도록 하고, 일주기 생체리듬 장애 및 퇴행성 뇌질환을 포함한 생체리듬 관련 질환 모델 검사에 활용이 가능하다.

Stable olfactory receptor activation across odor complexity

2025-10-31T15:00:00Z

Title: Stable olfactory receptor activation across odor complexity Author(s): Kim, Minseok; Lee, Jeongyoon; Park, Inah; Kim, Jihoon; Lee, Keunsoon; So, Jinhyun; Choi, Ji-Woong; Jang, Jae Eun; Kwon, Hyuk-Jun; Moon, Cheil; Choe, Han Kyoung Abstract: Mechanisms underlying single odorant activation of specific olfactory receptors are well understood. However, how the olfactory system processes complex odor mixtures at the receptor level remains unclear. This study examined olfactory receptor activation patterns across odor complexities using phosphoTRAP analysis. For most mixtures, receptor activation patterns closely matched the linear sum of individual component responses. However, distinct receptor sets display non-linear responses unexplained by linear models. Mixture responses were generally located between component responses and often aligned with linear predictions, though some deviations indicated non-linear interactions. Total activated receptors remained relatively constant regardless of odor complexity, suggesting efficient coding that prevented receptor saturation as odorant components increased. These findings provide receptor-level evidence that the olfactory system encodes complex odors primarily through linear integration of receptor activity, with added specificity from non-linear responses in limited receptors, advancing understanding of how the olfactory system normalizes receptor activation in response to natural odors.

Hexagonal metal complex based mechanically robust transparent ultrathin gold μECoG for electro-optical neural interfaces

2025-03-31T15:00:00Z

Title: Hexagonal metal complex based mechanically robust transparent ultrathin gold μECoG for electro-optical neural interfaces Author(s): Kim, Duhee; Bissannagari, Murali; Kim, Boil; Hong, Nari; Park, Jaeu; Lim, Hyeongtae; Lee, Junhee; Lee, Jungha; Kim, Yoon Kyoung; Cho, Youngjae; Lee, Kwang; Lee, Junghyup; Yoon, Jong-Hyeok; Jang, Jae Eun; Tsai, David; Lee, Sanghoon; Kwon, Hyuk-Jun; Choe, Han Kyoung; Kang, Hongki Abstract: Transparent electro-optical neural interfacing technologies offer simultaneous high-spatial-resolution microscopic imaging, and high-temporal-resolution electrical recording and stimulation. However, fabricating transparent, flexible, and mechanically robust neural electrodes with high electrochemical performance remains challenging. In this study, we fabricated transparent (72.7% at 570 nm), mechanically robust (0.05% resistance change after 50k bending cycles) ultrathin Au microelectrodes for micro-electrocorticography (mu ECoG) using a hexadentate metal-polymer ligand bonding with an EDTA/PSS seed layer. These transparent mu ECoG arrays, fabricated with biocompatible gold, exhibit excellent electrochemical properties (0.73 Omegacm2) for neural recording and stimulation with long-term stability. We recorded brain surface waves in vivo, maintaining a low baseline noise and a high signal-to-noise ratio during acute and two-week recordings. In addition, we successfully performed optogenetic modulation without light-induced artifacts at 7.32 mW/mm2 laser power density. This approach shows great potential for scalable, implantable neural electrodes and wearable optoelectronic devices in digital healthcare systems.

Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair

2024-12-31T15:00:00Z

Title: Activation of TMEM16E scramblase induces ligand independent growth factor receptor signaling and macropinocytosis for membrane repair Author(s): Kim, Jung-Eun; Ko, Woori; Jin, Siwoo; Woo, Jin-Nyeong; Jung, Yuna; Bae, Inah; Choe, Han Kyoung; Seo, Daeha; Hille, Bertil; Suh, Byung-Chang Abstract: The calcium-dependent phospholipid scramblase TMEM16E mediates ion transport and lipid translocation across the plasma membrane. TMEM16E also contributes to protection of membrane structure by facilitating cellular repair signaling. Our research reveals that TMEM16E activation promotes macropinocytosis, essential for maintaining plasma membrane integrity. This scramblase externalizes phosphatidylserine, typically linked to resting growth factor receptors. We demonstrate that TMEM16E can interact with and signal through growth factor receptors, including epidermal growth factor receptor, even without ligands. This interaction stimulates downstream phosphoinositide 3-kinase and facilitates macropinocytosis and internalization of annexin V bound to the membrane, a process sensitive to amiloride inhibition. Although TMEM16E is internalized during this process, it returns to the plasma membrane. TMEM16E- driven macropinocytosis is proposed to restore membrane integrity after perturbation, potentially explaining pathologies in conditions like muscular dystrophies, where TMEM16E functionality is compromised, highlighting its critical role in muscle cell survival.