https://scholar.dgist.ac.kr/handle/20.500.11750/8969 -The conception, design and creation of combinatorial antibodies- 2026-04-04T15:17:59Z https://scholar.dgist.ac.kr/handle/20.500.11750/59240 Title: 사이토카인 및 항체를 발현하는 세포외 소포체, 이를 제조하는 방법 및 이의 용도 Author(s): 예경무; 백문창; 조한채 https://scholar.dgist.ac.kr/handle/20.500.11750/59228 Title: Reconciling a Kinetic Model for Dimerization of the EGFR Using Single-Molecule Tracking in Living Cells Author(s): Kim, Kiwook; Jang, Juhee; Cho, Juhyeong; Ahn, Yongdeok; Jeong, Seunghyeon; Shin, Jiwon; Yea, Kyungmoo; Lee, Wonhee John; Seo, Daeha Abstract: Epidermal growth factor receptor (EGFR) dimerization plays a pivotal role in cellular signaling, influencing proliferation and disease progression, particularly in cancer. Despite extensive studies, the quantitative relationship between EGFR expression levels and dimerization efficiency remains incompletely understood. In this study, we investigated EGFR dimerization kinetics using ensemble-level biochemical assays and single-molecule tracking (SMT) in living cells. Our findings revealed noncanonical negative cooperative dimerization, where the monomer-to-dimer transition rate decreased as EGFR expression increased, challenging the assumptions of a simplistic reaction model. Furthermore, we identified a dimer-specific degradation pathway highlighting the open-system nature of the plasma membrane environment. These findings establish a quantitative framework for understanding EGFR dimerization dynamics, offering insights into the complex regulatory principles governing membrane protein interactions. This model not only improves our understanding of EGFR-mediated signaling but also suggests broader applicability for the therapeutic targeting of membrane protein systems. 2025-08-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/59202 Title: METHOD FOR SCREENING FOR AGONIST ANTIBODIES THAT INDUCE RECEPTOR DIMERIZATION Author(s): 정인성; 정종원; 김지석; 박준국; 예경무 Abstract: The present invention relates to a method for screening for agonist antibodies that induce receptor dimerization. The screening method according to one embodiment enables the identification of agonist antibodies that mimic the signaling mechanism of natural signaling molecules and, in particular, enables complex screening for heterodimerization of single receptors or receptors that function by inducing homodimerization, and also of various types of receptors. https://scholar.dgist.ac.kr/handle/20.500.11750/59163 Title: GFRAL antagonistic antibodies and uses thereof Author(s): 정종원; 이범용; 신지원; 박준국; 예경무 Abstract: The present invention relates to GFRAL antagonist antibodies and uses thereof, and more specifically, to anti-GFRAL antibodies comprising heavy chain CDR and light chain CDR of specific sequences, and antigen-binding fragments thereof. Anti-GFRAL antibodies are expected to be useful in the alleviation or treatment of cancer-related anorexia-cachexia syndrome, as well as adverse reactions caused by chemotherapeutics.