https://scholar.dgist.ac.kr/handle/20.500.11750/10037 Sat, 04 Apr 2026 13:35:10 GMT 2026-04-04T13:35:10Z https://scholar.dgist.ac.kr/handle/20.500.11750/59285 Title: Ultra-thin high-resolution transfer-printed breathable electronics for conformal wearable devices Author(s): Choi, Hyeokjoo; Lee, Dongju; Hwang, Sieun; Shin, Juhee; Bae, Jihoon; Jang, Gain; Kwon, Seokhun; Kang, Hyunil; Myeong, Jihyeon; Jeong, Youngtae; Roh, Jong Wook; Lee, Sungwon Abstract: Nanomesh electronics offer remarkable potential for biomedical and human–machine interface applications due to their conformability to nonplanar surfaces, versatile functionality, and long-term reliability. However, existing materials face significant challenges related to surface structure and chemical resistance, resulting in high electrical resistance and complex fabrication requirements. To address these challenges, we present transfer-printed nanomesh electrodes (NEs) produced by integrating fine-patterned 2D electrodes with porous nanomesh. Electrospun thermoplastic-polyurethane nanofibers provide strong adhesion to the electrodes, which generate sufficient force (95.1 mN∙cm−1) to maintain structural integrity and electrical performance. Unlike direct deposition, which requires a minimum thickness of 100nm to achieve 14.12±2 mS, transfer-printed NEs reach 16.91±8.7 mS only with 20nm. Furthermore, our electrodes demonstrate excellent durability under deformation, maintaining stable electrical performance with only a 0.53% change at a bending radius of 1mm. To validate their practical application, we demonstrate a NE-based tactile sensor, which exhibits a conductance change from 0 mS in the normal state to 130 mS upon touch. These results highlight the potential of transfer-printed NEs for next-generation e-skin with fine patterning, high conductivity, and long-term reliability. In addition, our novel method addresses the challenges of manufacturing breathable devices with functionalities extending beyond simple electrodes. Sun, 30 Nov 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/59285 2025-11-30T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/59055 Title: Tissue-specific iron levels modulate lipid peroxidation and the FLASH radiotherapy effect Author(s): Vilaplana-Lopera, Nuria; Kim, Jiyoung; Nam, Gilyeong; Tullis, Iain D. C.; Paillas, Salome; Ruan, Jia-Ling; Lee, Pei Ju; Jiang, Yanyan; Park, Sohee; Hou, Tianxu; Nasir, Ayesha; Charlesworth, Eve; Walker, Ellie; Abu-Halawa, Ammar; Hill, Mark A.; Choi, Changhoon; Lee, Ik Jae; Jeong, Youngtae; Lakhal-Littleton, Samira; Then, Chee Kin; Shen, Shing-Chuan; Giaccia, Amato J.; Petersson, Kristoffer; Moon, Eui Jung Abstract: Iron is vital to living cells, playing a key role in cellular respiration, DNA synthesis, and various metabolic functions. Importantly, cancer cells have a higher dependency on iron compared to normal cells to support their rapid growth and survival. Due to this fact, tumors are more vulnerable to ferroptosis, an iron-dependent form of regulated cell death. Radiation therapy (RT), a standard treatment for many cancer patients, is known to induce ferroptosis. Ultra-high dose rate FLASH RT offers an improved therapeutic window by minimizing damage to normal tissues while preserving tumor control. However, the precise biological mechanisms behind the protective effects of FLASH RT on normal tissues remain unclear. In this study, we propose that variations in lipid peroxidation and ferroptosis, driven by intrinsic differences in iron levels between normal and cancerous tissues, contribute to this effect. Our findings show that FLASH RT increases lipid peroxidation and induces ferroptosis in tumor cells but does not significantly elevate lipid peroxidation and ferroptosis in normal tissues compared to conventional RT. To determine whether raising iron levels in normal tissues could abrogate the protective effects of FLASH, mice were fed a high-iron diet before RT. A high-iron diet before and after RT reversed the protective effect of FLASH, resulting in increased intestinal damage and lipid peroxidation. This suggests that baseline iron levels and iron-driven lipid peroxidation are critical factors in mediating the protective outcomes of FLASH RT. Overall, our study sheds light on the role of iron in modulating RT responses and provides new mechanistic insights into how FLASH RT influences normal and cancerous tissues. © 2025 Elsevier B.V., All rights reserved. Sun, 31 Aug 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/59055 2025-08-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58300 Title: Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells Author(s): Myeong, Jihyeon; Lee, Minho; Lee, Bawool; Kim, Joon Hyung; Nam, Yeji; Choi, Yeseul; Kim, Jeongmin; Jeon, Se Young; Shim, Haewon; Jung, Da-Ryung; Shin, Youngjin; Jeong, Minsoo; Oh, Byungmoo; Jung, Jaehun; Kim, Christine S.; Han, Hyung Soo; Shin, Jae-Ho; Lee, Yoon Hee; Park, Nora Jee-Young; Chong, Gun Oh; Jeong, Youngtae Abstract: Cervical cancer is the fourth most common female cancer, with the uterine ectocervix being the most commonly affected site. However, cervical stem cells, their differentiation, and their regulation remain poorly understood. Here, we report the isolation of a population enriched for human cervical stem cells and their regulatory mechanisms. Using single-cell RNA sequencing, we characterize the cellular heterogeneity of the human ectocervix and identify cluster-specific cell surface markers. By establishing normal and precancerous cervical organoids and an intralingual transplantation system, we show that ITGB4 and CD24 enable enrichment of human and murine ectocervical stem cells. We discover that Lactobacilli-derived lactic acid regulates cervical stem cells’ self-renewal and early tumorigenesis through the PI3K-AKT pathway and YAP1. Finally, we show that D-lactic acid suppresses growth of normal and precancerous organoids, while L-lactic acid does not. Our findings reveal roles of human cervical stem cells and microbial metabolites in cervical health and diseases. © The Author(s) 2025. Fri, 28 Feb 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/58300 2025-02-28T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/57322 Title: IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells Author(s): Noh, Soojeong; Ryu, Suyeon; Jung, Dokyung; Shin, Sanghee; Jung, Inseong; Kang, Sung-Min; Kim, Christine S.; Choi, Sung-Jin; Cho, Hanchae; Schwämmle, Melanie; Jeong, Youngtae; Bucher, Felicitas; Choi, Il-Kyu; Lee, Shin Yup; Im, Sin-Hyeog; Yea, Kyungmoo; Baek, Moon-Chang Abstract: [No Abstract Available] Sat, 30 Nov 2024 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/57322 2024-11-30T15:00:00Z