https://scholar.dgist.ac.kr/handle/20.500.11750/173 Sat, 04 Apr 2026 08:22:33 GMT 2026-04-04T08:22:33Z https://scholar.dgist.ac.kr/handle/20.500.11750/59929 Title: Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy Author(s): Seo-Jin Oh; Jin-jyeok Jang; Jean-Pierre Roussarie; Gyeong-un Jang; Min-seok Jeong; Yeon Suk Jo; Chang-Hoon Shin; Hongsoo Choi; Kwang Lee; Yoon, Jong-Hyeok; Yong-Seok Oh Abstract: Selective serotonin reuptake inhibitors (SSRIs) exhibit delayed therapeutic effects despite rapid serotonin elevation, suggesting their dependence on slow neuroplastic adaptations. Here, we demonstrate that antidepressant actions require cell type-specific translational regulation of the peptidergic signaling in the dentate gyrus (DG). Chronic, but not acute, treatment with an SSRI fluoxetine (FLX) selectively enhances translational activity in hilar mossy cells (MCs), with no detectable changes in neighboring granule cells (GCs). Combining Translating Ribosome Affinity Purification (TRAP) with RNA sequencing revealed distinct baseline translatomes between these two glutamatergic neurons and identified FLX-induced remodeling of peptidergic pathways in the DG. Crucially, we discovered MC-specific enrichment of the neuropeptide PACAP, which undergoes translation-dependent upregulation by chronic FLX treatment. This PACAP induction mediates neuroadaptive plasticity in PAC1 receptor-expressing GCs and drives behavioral responses prominently in female mice during prolonged FLX administration. Our findings establish cell type-specific translational reprogramming as a novel mechanistic framework for antidepressant action. https://scholar.dgist.ac.kr/handle/20.500.11750/59929 https://scholar.dgist.ac.kr/handle/20.500.11750/59397 Title: Dual Active Tilted Roller Actuation System (DATRAS) with an electromagnetic actuation system for vascular intervention Author(s): Chowdhury, A. M. Masum Bulbul; Gharamaleki, Nader Latifi; Lee, Hakjoon; Kim, Jin-Young; Kim, Minsoo; Vidal, Salvador Pane i Vidal; Youn, Sung Won; Choi, Hongsoo Abstract: This paper presents DATRAS (Dual Active Tilted Roller Actuation System), a compact robotic system for vascular interventions that integrates with electromagnetic actuation systems to enable complete teleoperation. DATRAS combines translation and rotation motion for intervention tools in a single module, simplifying design and control. The system also allows easy roller adjustment for various tool diameters and enables guidewire helical motion without additional components or specialized guidewires. Experimental validation using cerebrovascular and cardiovascular phantoms demonstrates DATRAS’s effectiveness in controlling magnetic tip guidewire motion when combined with electromagnetic actuation. Weighing just 320 g, this lightweight device aims to enhance interventional procedures by facilitating easy manipulation of instruments through teleoperation. The actuator addresses current limitations in robotic intervention systems, exhibiting a potential reduction in radiation exposure and ergonomic risks for medical professionals, ultimately improving the efficacy of vascular interventions. Mon, 31 Mar 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/59397 2025-03-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/59061 Title: Optimized Coil Design for Enhanced Electric Field Induction in Peripheral Nerve Stimulation Author(s): Park, Jaeu; Lee, Kyeong Jae; Nagwade, Pritish; Jeong, Jinwoong; Park, Jeong Hoan; Choi, Hongsoo; Kim, Sohee; Lee, Sanghoon Abstract: Peripheral nerve electrical stimulation is widely used for the treatment of neuropathic pain and neural regeneration. However, it often induces adverse biological reactions and unintended activation of surrounding neural tissues. As an alternative, peripheral nerve magnetic stimulation offers a promising, less invasive approach that enables targeted nerve stimulation without direct tissue contact. Despite its potential, it is constrained by the bulkiness of coils and excessive heat generation due to the high currents required. To address these limitations, we conducted a study on coil design optimized for peripheral nerve modulation. Our approach, supported by simulations and animal experiments, focused on optimizing coil geometry to maximize the induced electric field gradient. Among various designs, a four-leaf rhombus-shaped coil demonstrated the highest gradient at the center of the interface. In rat sciatic nerve experiments, this coil, driven by a rectangular pulse with a 200 μs rise time and 25 V amplitude, successfully elicited compound muscle action potentials in both the tibial anterior and gastrocnemius muscles. This study presents design guidelines for peripheral nerve stimulation (PNS) coils based on magnetic stimulation as an alternative to conventional electrical stimulation. The proposed approach may serve as a foundation for the development of advanced, miniaturized, and energy-efficient neural stimulation coils. © 2025 Elsevier B.V., All rights reserved. Thu, 31 Jul 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/59061 2025-07-31T15:00:00Z https://scholar.dgist.ac.kr/handle/20.500.11750/58691 Title: Technology Roadmap of Micro/Nanorobots Author(s): Ju, Xiaohui; Chen, Chuanrui; Oral, Cagatay M.; Sevim, Semih; Golestanian, Ramin; Sun, Mengmeng; Bouzari, Negin; Lin, Xiankun; Urso, Mario; Nam, Jong Seok; Cho, Yujang; Peng, Xia; Landers, Fabian C.; Yang, Shihao; Adibi, Azin; Taz, Nahid; Wittkowski, Raphael; Ahmed, Daniel; Wang, Wei; Magdanz, Veronika; Medina-Sánchez, Mariana; Guix, Maria; Bari, Naimat; Behkam, Bahareh; Kapral, Raymond; Huang, Yaxin; Tang, Jinyao; Wang, Ben; Morozov, Konstantin; Leshansky, Alexander; Abbasi, Sarmad Ahmad; Choi, Hongsoo; Ghosh, Subhadip; Borges Fernandes, Bárbara; Battaglia, Giuseppe; Fischer, Peer; Ghosh, Ambarish; Jurado Sánchez, Beatriz; Escarpa, Alberto; Martinet, Quentin; Palacci, Jérémie; Lauga, Eric; Moran, Jeffrey; Ramos-Docampo, Miguel A.; Städler, Brigitte; Herrera Restrepo, Ramón Santiago; Yossifon, Gilad; Nicholas, James D.; Ignés-Mullol, Jordi; Puigmartí-Luis, Josep; Liu, Yutong; Zarzar, Lauren D.; Shields, C. Wyatt; Li, Longqiu; Li, Shanshan; Ma, Xing; Gracias, David H.; Velev, Orlin; Sánchez, Samuel; Esplandiu, Maria Jose; Simmchen, Juliane; Lobosco, Antonio; Misra, Sarthak; Wu, Zhiguang; Li, Jinxing; Kuhn, Alexander; Nourhani, Amir; Maric, Tijana; Xiong, Ze; Aghakhani, Amirreza; Mei, Yongfeng; Tu, Yingfeng; Peng, Fei; Diller, Eric; Sakar, Mahmut Selman; Sen, Ayusman; Law, Junhui; Sun, Yu; Pena-Francesch, Abdon; Villa, Katherine; Li, Huaizhi; Fan, Donglei Emma; Liang, Kang; Huang, Tony Jun; Chen, Xiang-Zhong; Tang, Songsong; Zhang, Xueji; Cui, Jizhai; Wang, Hong; Gao, Wei; Kumar Bandari, Vineeth; Schmidt, Oliver G.; Wu, Xianghua; Guan, Jianguo; Sitti, Metin; Nelson, Bradley J.; Pané, Salvador; Zhang, Li; Shahsavan, Hamed; He, Qiang; Kim, Il-Doo; Wang, Joseph; Pumera, Martin Abstract: Inspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to scaling up production, commercialization, and regulatory frameworks that are crucial for transitioning from research to practical applications. We also emphasize the need for interdisciplinary collaboration to address both technical and nontechnical challenges, such as sustainability, ethics, and business considerations. Finally, we propose a roadmap for future research to accelerate the development of micro/nanorobots, positioning them as essential tools for addressing grand challenges and enhancing the quality of life. © 2025 The Authors. Published by American Chemical Society. Sat, 31 May 2025 15:00:00 GMT https://scholar.dgist.ac.kr/handle/20.500.11750/58691 2025-05-31T15:00:00Z