https://scholar.dgist.ac.kr/handle/20.500.11750/6319 Sun, 20 Sep 2026 15:14:12 GMT 2026-09-20T15:14:12Z https://scholar.dgist.ac.kr/handle/20.500.11750/60695 Title: ANKS1A 단백질 변이체 또는 이를 암호화하는 폴리뉴클레오타이드를 이용한 알츠하이머 질병 진단 방법 Author(s): 박수철; 서진수; 박선아 Abstract: ANKS1A-A355D 단백질 변이체는 알츠하이머 환자에게서 발견되며, 정상적인 ANKS1A 단백질과 달리, LRP1 수용체의 세포막 발현을 유도하지 못하기 때문에 효율적으로 베타 아밀로이드 펩타이드와 같은 독성 단백질을 제거하지 못한다. 따라서, ANKS1A-A355D 단백질 변이체의 발현수준을 확인하거나 ANKS1A-A355D 단백질 변이체를 암호화하는 유전자 보유여부를 검출하여 알츠하이머 질병 발병에 대한 조기 진단 정보를 제공하는 방법을 제공한다. 또한, ANKS1A-A355D 단백질 변이체 또는 이를 암호화하는 폴리뉴클레오티드를 검출하는 제제를 포함하는 조성물을 제공한다. https://scholar.dgist.ac.kr/handle/20.500.11750/60695 https://scholar.dgist.ac.kr/handle/20.500.11750/59044 Title: COMPOSITION FOR TREATING ALZHEIMER`S DISEASE COMPRISING AS ACTIVE INGREDIENT MIXED EXTRACT OF PINELLIA TERNATA BREITENBACH, ZIZYPHUS JUJUBA VAR. INERMIS REHDER, GLYCYRRHIZA URALENSIS FISCHER, PANAX GINSENG, ZINGIBER OFFICINALE ROSCOE, SCUTELLARIA BAICALENSIS, AND COPTIS RHIZOME Author(s): 김재광; 박여진; 서진수; 최장기; 김부윤; 박맑은; 오태우; 고영훈; 이혜인 Abstract: The present invention relates to use of a composition comprising Banhasasim-tang as an active ingredient for the treatment, amelioration or prevention of Alzheimer's disease caused by ApoE4 genetic variation. The composition comprising Banhasasim-tang as an active ingredient and a treatment method, according to the present invention, exhibit excellent effects of reducing amyloid beta protein and inhibiting the precipitation thereof in a manner specific to Alzheimer's disease caused by ApoE4 genetic variation, and thus are greatly used as a preventive, ameliorating or therapeutic composition specific to Alzheimer's disease caused by ApoE4 genetic variation. https://scholar.dgist.ac.kr/handle/20.500.11750/59044 https://scholar.dgist.ac.kr/handle/20.500.11750/59042 Title: METHOD FOR DIAGNOSING ALZHEIMER`S DISEASE BY USING ANKS1A PROTEIN VARIANT OR POLYNUCLEOTIDE ENCODING SAME Author(s): 서진수; 박선아; 박수철 Abstract: An ANKS1A-A355D protein variant is found in Alzheimer's disease patients, and unlike a normal ANKS1A protein, is unable to induce the cell membrane expression of an LRP1 receptor, and thus is unable to efficiently remove toxic proteins such as an amyloid beta peptide. Therefore, provided is a method for providing early diagnosis information on the onset of Alzheimer's disease by confirming the expression level of an ANKS1A-A355D protein variant or detecting the presence or absence of a gene encoding the ANKS1A-A355D protein variant. Also, provided is a composition comprising an agent for detecting an ANKS1A-A355D protein variant or a polynucleotide encoding same. https://scholar.dgist.ac.kr/handle/20.500.11750/59042 https://scholar.dgist.ac.kr/handle/20.500.11750/58829 Title: Composition for treating alzheimer's disease comprising mixed extract of pinellia ternate, jujube, liquorice, ginseng, rhizoma zingiberis, scutellaria baicalensis and coptis chinensis as active ingredient Author(s): 서진수; 고영훈; 김재광; 박맑은; 이혜인; 최장기; 박여진; 오태우; 김부윤 Abstract: The invention relates to a composition for treating, improving or preventing Alzheimer's disease caused by ApoE4 gene mutation. The composition comprises pinellia ternate heart-fire purging decoction as an active ingredient. The composition containing the pinellia ternate heart-fire purging decoction as an active ingredient and the treatment method show excellent effects of reducing beta amyloid protein (which is specific to Alzheimer's disease caused by ApoE4 gene mutation) and inhibiting deposition of the beta amyloid protein; thus, the composition has high applicability as a specific composition for preventing, ameliorating or treating Alzheimer's disease caused by ApoE4 gene mutation. https://scholar.dgist.ac.kr/handle/20.500.11750/58829