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Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments

Title
Development of Magnetically Driven Microrobots for Targeted Cell Delivery, and Their Characterization in in Vitro, Ex Vivo and in Vivo Environments
Authors
Jeon, SungwoongPark, Sun HwaKim S.W.Kim, Jin-youngChoi, Hongsoo
DGIST Authors
Kim, Jin-youngChoi, Hongsoo
Issue Date
2020-01-19
Citation
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, 2-5
Type
Conference
ISBN
9781728135809
ISSN
1084-6999
Abstract
Here, we propose magnetically driven microrobots for targeted cell delivery that can efficiently swim in various physiological environments. The three-dimensional (3D) microrobots were sophisticatedly fabricated by using micro-electro-mechanical systems (MEMS) technologies such as 3D laser lithography and metal sputtering. The magnetic field generated by an electromagnetic coil system allows efficient wireless actuation of the microrobots, which was characterized in various physiological conditions (in vitro viscous fluid, ex vivo rat brain blood vessels and a live nude mouse intraperitoneal cavity (in vivo)). Especially, the microrobots demonstrated stem cell transportation inside the body cavity of the nude mouse as a proof of concept of targeted cell delivery. Through this study, the use of the proposed microrobots has shown the feasibility of future applications in precision medicine. © 2020 IEEE.
URI
http://hdl.handle.net/20.500.11750/11803
DOI
10.1109/MEMS46641.2020.9056365
Publisher
Institute of Electrical and Electronics Engineers Inc.
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab2. Conference Papers


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