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96-Well Format-Based Microfluidic Platform for an in-Vitro Multiple Micro-Organ Network
- 96-Well Format-Based Microfluidic Platform for an in-Vitro Multiple Micro-Organ Network
- Jin, Chaewon; Kim, Jin-young; Choi, Hongsoo
- DGIST Authors
- Kim, Jin-young; Choi, Hongsoo
- Issue Date
- 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, 1002-1005
- In this study, we have established 5 different micro-organs (Cortex-Hippocampus-Heat-Liver-Tumor) network in vitro in the 96-well format-based microfluidic platform by physically separating but fluidically interconnecting spherical microtissues (MTs) via the microfluidic channel. An effect of the anti-cancer drug, 5-fluorouaracil (5-FU), on tumor MT and also other organotypic MTs was investigated with their interaction through microfluidic network in vitro for 3-day cultivation While no significant suppression was observed when tumor MTs were solely cultured in 5-FU, growth of tumor MTs was suppressed in the in vitro 5 micro-organ network without critical impact on the other 4 MTs. It addresses feasibility of our microfluidic platform for more complex and comprehensive pharmacokinetic study in an in vivo-like in vitro physiological environment. © 2020 IEEE.
- Institute of Electrical and Electronics Engineers Inc.
- Related Researcher
Bio-Micro Robotics Lab
Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
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- Department of Robotics EngineeringBio-Micro Robotics Lab2. Conference Papers
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