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96-Well Format-Based Microfluidic Platform for an in-Vitro Multiple Micro-Organ Network

Title
96-Well Format-Based Microfluidic Platform for an in-Vitro Multiple Micro-Organ Network
Authors
Jin, ChaewonKim, Jin-youngChoi, Hongsoo
DGIST Authors
Kim, Jin-youngChoi, Hongsoo
Issue Date
2020-01-19
Citation
33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, 1002-1005
Type
Conference
ISBN
9781728135809
ISSN
1084-6999
Abstract
In this study, we have established 5 different micro-organs (Cortex-Hippocampus-Heat-Liver-Tumor) network in vitro in the 96-well format-based microfluidic platform by physically separating but fluidically interconnecting spherical microtissues (MTs) via the microfluidic channel. An effect of the anti-cancer drug, 5-fluorouaracil (5-FU), on tumor MT and also other organotypic MTs was investigated with their interaction through microfluidic network in vitro for 3-day cultivation While no significant suppression was observed when tumor MTs were solely cultured in 5-FU, growth of tumor MTs was suppressed in the in vitro 5 micro-organ network without critical impact on the other 4 MTs. It addresses feasibility of our microfluidic platform for more complex and comprehensive pharmacokinetic study in an in vivo-like in vitro physiological environment. © 2020 IEEE.
URI
http://hdl.handle.net/20.500.11750/11805
DOI
10.1109/MEMS46641.2020.9056388
Publisher
Institute of Electrical and Electronics Engineers Inc.
Related Researcher
  • Author Choi, Hongsoo Bio-Micro Robotics Lab
  • Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
Files:
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Collection:
Department of Robotics EngineeringBio-Micro Robotics Lab2. Conference Papers


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