Comparing the difference in expression of exosomal biomarkers between exosomes from serum and tissue in cancer patients

Abstract

Exosomes, nano-sized extracellular vesicles, are reported to harbor signaling molecules to communicate between remote cells. Due to this reason, exosomal biomarkers have received interests as a source of early detection of cancers. To determine whether the exosomes affect tumor progression in cancer patients, we primarily identified the changes in exosomal protein contents exosomes from serum in cancer patient. We select the best exosomal biomarkers from exosomes in cancer patients. In this study, we compared the expression level of exosomal biomarkers in serum exosomes of cancer patients vs. tissue of cancer patients. Exosomal biomarkers were detected at higher levels in serum exosome from cancer patients compared to tissue. These results suggest that increased exosomal biomarkers from serum exosomes in cancer patients is associated with cancer progression.