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Ambient laser desorption of mouse hippocampal tissue slice on graphene layer substrate for high spatial resolution mass spectrometric imaging

Title
Ambient laser desorption of mouse hippocampal tissue slice on graphene layer substrate for high spatial resolution mass spectrometric imaging
Authors
Kim, Jae YoungLee, SunYoungLim, Hee JinPark, Ji-WonLim, Dong-KwonMoon, DaeWon
DGIST Authors
Kim, Jae Young
Issue Date
2018-08-23
Citation
2018 한국질량분석학회 여름정기학술대회
Type
Conference
Abstract
We report an ambient MS imaging system with efficient desorption procedures by using 532 nm-continuous wave (CW) laser and graphene layer substrate for ambient desorption and subsequent ionization step with an aid of plasma system. In order to facilitate the desorption process in this system, the use of a suitable material respond to the 532 nm laser is essential, so that a graphene layer was used as a light absorbing substrate at a visible wavelength. The graphene layer absorbs mainly the light energy in the UV wavelength, but also absorbs the visible wavelength quite well, so that the visible laser can be used as an ambient desorption source with the help of a graphene layer. Graphene can respond to multiple wavelengths because of broad and strong light absorption property in the visible region of light, which can widen the availability of light source for sample desorption. Instead of using gold nanoparticles that serve as light energy reservoirs inside the specimen, the fabrication of a light absorbing layer on the substrate allows for fast and simple specimen preparation with no additional pre-treatment, so that biological specimens that have difficulty in analysis due to complicated specimen preparation can be successfully analyzed with this MS method.
URI
http://hdl.handle.net/20.500.11750/14810
Publisher
한국질량분석학회
Files:
There are no files associated with this item.
Collection:
Department of Robotics and Mechatronics EngineeringRobotics Engineering Research Center2. Conference Papers


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