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dc.contributor.author 정진우 -
dc.contributor.author 최영현 -
dc.date.accessioned 2023-07-24T20:10:24Z -
dc.date.available 2023-07-24T20:10:24Z -
dc.date.created 2017-04-20 -
dc.date.issued 2014-01 -
dc.identifier.issn 1226-3311 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/46257 -
dc.description.abstract Cordycepin is the major functional component of Cordyceps species and is widely used in traditional oriental medicine. Cordycepin has been shown to possess many pharmacological properties, such as enhancement of immune function along with anti-inflammatory, antioxidant, anti-aging, and anti-cancer effects. Here, we investigated the inhibitory effects of cordycepin on cell migration and invasion, which are two critical cellular processes that are often deregulated during metastasis, using HCT116 human colorectal carcinoma cells. According to our data, cordycepin at non-cytotoxic concentrations markedly inhibited the motility and invasiveness of HCT116 cells in a time-dependent manner. RT-PCR and Western blotting results indicated that cordycepin reduced the levels of claudin proteins, which are major components of tight junctions (TJs), and induced tightening of TJs. Cordycepin also attenuated the expression and activities of matrix metalloproteinases (MMPs)-2 and -9, whereas levels of tissue inhibitor of metalloproteinases (TIMPs)-1 and -2 were simultaneously elevated. These findings suggest that cordycepin reduces the migration and invasion of HCT116 cells by modulating the activities of TJs and MMPs. -
dc.language Korean -
dc.publisher 한국식품영양과학회 -
dc.title Cordycepin의 치밀결합 강화 및 MMPs의 활성 억제를 통한 HCT116 인체대장암세포의 이동성 및 침윤성의 억제 -
dc.title.alternative Cordycepin Inhibits Migration and Invasion of HCT116 Human Colorectal Carcinoma Cells by Tightening of Tight Junctions and Inhibition of Matrix Metalloproteinase Activity -
dc.type Article -
dc.identifier.doi 10.3746/jkfn.2014.43.1.086 -
dc.identifier.scopusid 2-s2.0-84929411124 -
dc.identifier.bibliographicCitation Journal of the Korean Society of Food Science and Nutrition, v.43, no.1, pp.86 - 92 -
dc.identifier.kciid ART001847624 -
dc.description.isOpenAccess FALSE -
dc.subject.keywordAuthor cordycepin -
dc.subject.keywordAuthor invasion -
dc.subject.keywordAuthor tight junctions -
dc.subject.keywordAuthor claudin -
dc.subject.keywordAuthor MMP -
dc.citation.endPage 92 -
dc.citation.number 1 -
dc.citation.startPage 86 -
dc.citation.title Journal of the Korean Society of Food Science and Nutrition -
dc.citation.volume 43 -
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