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Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus
- Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus
- Jeong, Byeong Ha; Hong, Jin Hee; Kim, Hyun; Choe, Han Kyoung; Kim, Kyung Jin; Lee, Kyoung J.
- DGIST Authors
- Choe, Han Kyoung
- Issue Date
- Scientific Reports, 6
- Article Type
- CELLULAR CLOCKS; NEURONS; NETWORK; TEMPERATURE; RHYTHMS; SCN; OSCILLATOR; SYNCHRONY; ORGANIZATION; SENSITIVITY
- The suprachiasmatic nucleus (SCN) is a group of cells that functions as a biological master clock. In different SCN cells, oscillations of biochemical markers such as the expression-level of clock genes, are not synchronized but instead form slow circadian phase waves propagating over the whole cell population spatio-temporal struc- ture is a fixed property set by the anatomy of a given SCN. Here, we show that this is not the case in early postnatal SCN. Earlier studies presumed that their Based on bioluminescence imaging experiments with Per2-Luciferase mice SCN cultures which guided computer simulations of a realistic model of the SCN, we demonstrate that the wave is not unique but can be in various modes including phase-coherent oscillation, crescent-shaped wave, and most notably, a rotating pinwheel wave that conceptually resembles a wall clock with a rotating hand. Furthermore, mode transitions can be induced by a pulse of 38.5 degrees C temperature perturbation. Importantly, the waves support a significantly different period, suggesting that neither a spatially-fixed phase ordering nor a specialized pacemaker having a fixed period exist in these studied SCNs. These results lead to new important questions of what the observed multi-stability means for the proper function of an SCN and its arrhythmia.
- Nature Publishing Group
- Related Researcher
Choe, Han Kyoung
Laboratory of Animal Behavior and Circadian rhythm
Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
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- Department of Brain and Cognitive SciencesLaboratory of Animal Behavior and Circadian rhythm1. Journal Articles
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