Cited 2 time in webofscience Cited 1 time in scopus

Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus

Title
Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus
Authors
Jeong, Byeong HaHong, Jin HeeKim, HyunChoe, Han KyoungKim, Kyung JinLee, Kyoung J.
DGIST Authors
Choe, Han Kyoung
Issue Date
2016-02
Citation
Scientific Reports, 6
Type
Article
Article Type
Article
Keywords
CELLULAR CLOCKSNEURONSNETWORKTEMPERATURERHYTHMSSCNOSCILLATORSYNCHRONYORGANIZATIONSENSITIVITY
ISSN
2045-2322
Abstract
The suprachiasmatic nucleus (SCN) is a group of cells that functions as a biological master clock. In different SCN cells, oscillations of biochemical markers such as the expression-level of clock genes, are not synchronized but instead form slow circadian phase waves propagating over the whole cell population spatio-temporal struc- ture is a fixed property set by the anatomy of a given SCN. Here, we show that this is not the case in early postnatal SCN. Earlier studies presumed that their Based on bioluminescence imaging experiments with Per2-Luciferase mice SCN cultures which guided computer simulations of a realistic model of the SCN, we demonstrate that the wave is not unique but can be in various modes including phase-coherent oscillation, crescent-shaped wave, and most notably, a rotating pinwheel wave that conceptually resembles a wall clock with a rotating hand. Furthermore, mode transitions can be induced by a pulse of 38.5 degrees C temperature perturbation. Importantly, the waves support a significantly different period, suggesting that neither a spatially-fixed phase ordering nor a specialized pacemaker having a fixed period exist in these studied SCNs. These results lead to new important questions of what the observed multi-stability means for the proper function of an SCN and its arrhythmia.
URI
http://hdl.handle.net/20.500.11750/5673
DOI
10.1038/srep21463
Publisher
Nature Publishing Group
Related Researcher
  • Author Choe, Han Kyoung CHOE LAB: Animal Behavior and Circadian rhythm
  • Research Interests Modulation of neural circuit; Circadian regulation of behavior and perception; Neurotechnology
Files:
There are no files associated with this item.
Collection:
Department of Brain and Cognitive SciencesCHOE LAB: Animal Behavior and Circadian rhythm1. Journal Articles


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