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흰쥐 삼차신경감각핵에서 P2X3와 TRPV1의 공존에 관한 연구

흰쥐 삼차신경감각핵에서 P2X3와 TRPV1의 공존에 관한 연구
Alternative Title
Coexpression of P2X3 with TRPV1 in the Rat Trigeminal Sensory Nuclei
DGIST Authors
Issued Date
P2X3TRPV1Trigeminal ganglionTrigeminal caudalisImmunofluorescence
Trigeminal primary afferents expressing P2X3 or transient receptor potential vanilloid 1 (TRPV1) are involved in the
transmission of nociceptive information. In order to characterize P2X3- and TRPV1-immunopositive neurons in the trigeminal
ganglion (TG) and trigeminal caudal nucleus (Vc), we performed immunofluorescence experiments using anti-
P2X3 and anti-TRPV1 antisera and a morphometric analysis.
77.4% (1,401/1,801) of all the P2X3-postive neurons coexpressed TRPV1 and 51.9% (1,401/2,698) of all the TRPV1-
immunopositive neurons also costained for P2X3 in the TG. Immunoreactivity for both P2X3 and TRPV1 were present in
medium-sized neurons but not in small- and large-sized neurons. P2X3- and/or TRPV1-immunopositive fibers were observed
in the primary afferents and their associated axons in the Vc. These fibers and terminals were distributed in the
superficial lamina of Vc: P2X3-immunopositive fibers and terminals were distributed in the lamina I and II, expecially in
the inner part of lamina II (lamina IIi), whereas TRPV1-immunopositive ones were densely detected in the lamina I and
outer part of lamina II (lamina IIo). Immunopositive fibers and terminals for both P2X3 and TRPV1 were observed on the
border between lamina IIi and IIo.
These results suggest that terminals coexpressing P2X3 and TRPV1 are involved in specific roles in the transmission
and processing of orofacial nociceptive information.
Related Researcher
  • 문제일 Moon, Cheil 뇌과학과
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
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Department of Brain Sciences Laboratory of Chemical Senses 1. Journal Articles


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