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Family of FLP peptides in Caenorhabditis elegans and related nematodes
- Family of FLP peptides in Caenorhabditis elegans and related nematodes
- Li, C[Li, Chris]; Kim, K[Kim, Kyuhyung]
- DGIST Authors
- Kim, K[Kim, Kyuhyung]
- Issue Date
- Frontiers in Endocrinology, 5
- Article Type
- Alpha Amidating Enzyme; Ascaris Suum; Avoidance Behavior; Behavior; Caenorhabditis Elegans; Chemosensitization; Cyclic AMP; Egg Laying; Endoplasmic Reticulum; Furin; G Protein-Coupled Receptor; Gene; Gene Expression; Heat Behavior; Immunoreactivity; Intracellular Signaling; Learning; Locomotion; Mating; Membrane Metalloendopeptidase; Memory; Metabolism; Motoneuron; Myosin Heavy Chain; Nematodes; Nerve Cell Network; Nervous System; Neural Circuits; Neuropeptide; Neuropeptides; Non-Human; Protein Secretion; Protein Tyrosine Phosphatase; Recombinase; Review; Sensory Nerve Cell; Sleep; Stress; Synapse; Synaptosomal Associated Protein 25; Syntaxin; Worms
- Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system have been identified. The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large family of genes encoding FMRFamide-related peptides (FaRPs). These genes, the flp genes, have been used as a starting point to identifying flp genes throughout Nematoda. Nematodes have the largest family of FaRPs described thus far. The challenges in the future are the elucidation of their functions and the identification of the receptors and signaling pathways through which they function. © 2014 Li and Kim.
- Frontiers Research Foundation
- Related Researcher
Kim, Kyu Hyung
The K. Kim Lab of Neurobehavior and Neural Circuits
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Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles
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