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Family of FLP peptides in Caenorhabditis elegans and related nematodes

Title
Family of FLP peptides in Caenorhabditis elegans and related nematodes
Authors
Li, C[Li, Chris]Kim, K[Kim, Kyuhyung]
DGIST Authors
Kim, K[Kim, Kyuhyung]
Issue Date
2014
Citation
Frontiers in Endocrinology, 5
Type
Article
Article Type
Review
Keywords
Alpha Amidating EnzymeAscaris SuumAvoidance BehaviorBehaviorCaenorhabditis ElegansChemosensitizationCyclic AMPEgg LayingEndoplasmic ReticulumFurinG Protein-Coupled ReceptorGeneGene ExpressionHeat BehaviorImmunoreactivityIntracellular SignalingLearningLocomotionMatingMembrane MetalloendopeptidaseMemoryMetabolismMotoneuronMyosin Heavy ChainNematodesNerve Cell NetworkNervous SystemNeural CircuitsNeuropeptideNeuropeptidesNon-HumanProtein SecretionProtein Tyrosine PhosphataseRecombinaseReviewSensory Nerve CellSleepStressSynapseSynaptosomal Associated Protein 25SyntaxinWorms
ISSN
1664-2392
Abstract
Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system have been identified. The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large family of genes encoding FMRFamide-related peptides (FaRPs). These genes, the flp genes, have been used as a starting point to identifying flp genes throughout Nematoda. Nematodes have the largest family of FaRPs described thus far. The challenges in the future are the elucidation of their functions and the identification of the receptors and signaling pathways through which they function. © 2014 Li and Kim.
URI
http://hdl.handle.net/20.500.11750/1151
DOI
10.3389/fendo.2014.00150
Publisher
Frontiers Research Foundation
Related Researcher
  • Author Kim, Kyu Hyung The K. Kim Lab of Neurobehavior and Neural Circuits
  • Research Interests
Files:
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Collection:
ETCETC
Brain and Cognitive SciencesThe K. Kim Lab of Neurobehavior and Neural Circuits1. Journal Articles


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