Design, fabrication, and characterization of magnetically actuated capsule and needle-type microrobots for targeted drug delivery
- Title
- Design, fabrication, and characterization of magnetically actuated capsule and needle-type microrobots for targeted drug delivery
- Alternative Title
- 표적지향형 약물전달을 위한 자기장 구동의 캡슐형 및 바늘형 마이크로로봇의 설계, 제작 및 특성평가
- Author(s)
- Seungmin Lee
- DGIST Authors
- Choi, Hongsoo ; Lee, Seungmin ; Nelson, Bradley J.
- Advisor
- 최홍수
- Co-Advisor(s)
- Bradley J. Nelson
- Issued Date
- 2020
- Awarded Date
- 2020-02
- Type
- Thesis
- Description
- 미세전자기계시스템, 이광자중합방식, 자성물질, 마이크로로봇, 약물 전달, 세포 전달
- Table Of Contents
-
List of Contents
ABSTRACT ······························································································ i
List of contents ···························································································v
List of figures ·························································································· ⅶ
List of tables ··························································································· xiⅱ
Chapter 1 Introduction 1
1.1 Background 1
1.2 Basic concept and related work 10
1.2.1 Magnetic materials 10
1.2.2 Fabrication of magnetic microrobot 13
1.2.3 Swimming strategy and external actuation system 15
1.2.4 Various medical microrobots for bio application 27
1.3 Motivation 37
1.4 Organization of the work 44
Chapter 2 Design and fabrication of microrobots 45
2.1 Fabrication principle using two-photon polymerization technique 46
2.1.1 Parameter test for fabrication 50
2.2 Design and fabrication of capsule-type microrobot 52
2.3 Design and fabrication of modular-type microrobot 55
2.4 Design and fabrication of needle-type microrobot 57
Chapter 3 Magnetic manipulation and behavior characterization of microrobots 61
3.1 Manipulation of capsule-type microrobot 62
3.2 Manipulation of modular-type microrobot 66
3.3 Manipulation of needle-type microrobot 69
3.4 Experimental set-up 74
3.4.1. Manipulation of the microrobot by an external magnetic field 74
3.4.2. Fabrication of microfluidic channel 75
3.4.3. Set-up of micro fluidic device for generating medium flow 76
Chapter 4 Numerical analysis of needle-type microrobot 77
4.1 Numerical analysis for fixation pressure of needle-type microrobot 77
Chapter 5 Cell and tissue experiment using capsule/needle-type microrobot 80
5.1 Cell experiment of capsule-type microrobot 81
5.1.1. Primary olfactory receptor neuron cell culture 81
5.1.2. Primary olfactory receptor neuron cell experiment using microrobot 82
5.1.3. Preparation of organotypic brain slice 82
5.2 Tissue experiment using needle-type microrobot 85
Chapter 6 Conclusions 90
6.1 Conclusions 91
6.2 Recommendations 93
6.2.1 Recommendations with respect to capsule-type microrobot 93
6.2.2 Recommendations with respect to modular-type microrobot 94
6.2.3 Recommendations with respect to needle-type microrobot 95
REFERENCES 96
요약문 103
APPENDIX 107
- URI
-
http://dgist.dcollection.net/common/orgView/200000282108
http://hdl.handle.net/20.500.11750/11979
- Degree
- Doctor
- Department
- Robotics Engineering
- Publisher
- DGIST
- Related Researcher
-
-
Choi, Hongsoo
- Research Interests Micro/Nano robot; Neural prostheses; MEMS; BMI; MEMS/NEMS; BioMEMS; MEMS 초음파 트랜스듀스; 인공와우
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- Appears in Collections:
- Department of Robotics and Mechatronics Engineering Theses Ph.D.
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