Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, SunYoung | - |
dc.contributor.author | Park, Ji Hwan | - |
dc.contributor.author | Kang, Un-Beom | - |
dc.contributor.author | Choi, Seong-Kyoon | - |
dc.contributor.author | Elfadi, Ahmed | - |
dc.contributor.author | Ullah, H M Arif | - |
dc.contributor.author | Chung, Myung-Jin | - |
dc.contributor.author | Son, Ji-Yoon | - |
dc.contributor.author | Yun, Hyun Ho | - |
dc.contributor.author | Park, Jae-Min | - |
dc.contributor.author | Yim, Jae-Hyuk | - |
dc.contributor.author | Jung, Seung-Jun | - |
dc.contributor.author | Kim, Sang-Hyup | - |
dc.contributor.author | Choi, Young-Chul | - |
dc.contributor.author | Kim, Dae-Seong | - |
dc.contributor.author | Shin, Jin-Hong | - |
dc.contributor.author | Park, Jin-Sung | - |
dc.contributor.author | Hur, Keun | - |
dc.contributor.author | Lee, Sang-Han | - |
dc.contributor.author | Lee, Eun-Joo | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Jeong, Kyu-Shik | - |
dc.date.accessioned | 2021-01-22T07:23:56Z | - |
dc.date.available | 2021-01-22T07:23:56Z | - |
dc.date.created | 2021-01-12 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | Cell Death Discovery, v.7, no.1, pp.1 | - |
dc.identifier.issn | 2058-7716 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/12747 | - |
dc.description.abstract | Among the three isoforms encoded by Rtn4, Nogo-A has been intensely investigated as a central nervous system inhibitor. Although Nogo-A expression is increased in muscles of patients with amyotrophic lateral sclerosis, its role in muscle homeostasis and regeneration is not well elucidated. In this study, we discovered a significant increase in Nogo-A expression in various muscle-related pathological conditions. Nogo−/− mice displayed dystrophic muscle structure, dysregulated muscle regeneration following injury, and altered gene expression involving lipid storage and muscle cell differentiation. We hypothesized that increased Nogo-A levels might regulate muscle regeneration. Differentiating myoblasts exhibited Nogo-A upregulation and silencing Nogo-A abrogated myoblast differentiation. Nogo-A interacted with filamin-C, suggesting a role for Nogo-A in cytoskeletal arrangement during myogenesis. In conclusion, Nogo-A maintains muscle homeostasis and integrity, and pathologically altered Nogo-A expression mediates muscle regeneration, suggesting Nogo-A as a novel target for the treatment of myopathies in clinical settings. © 2021, The Author(s). | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Nogo-A regulates myogenesis via interacting with Filamin-C | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41420-020-00384-x | - |
dc.identifier.wosid | 000605976800001 | - |
dc.identifier.scopusid | 2-s2.0-85098854466 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Cell Death Discovery | - |
dc.contributor.nonIdAuthor | Park, SunYoung | - |
dc.contributor.nonIdAuthor | Park, Ji Hwan | - |
dc.contributor.nonIdAuthor | Kang, Un-Beom | - |
dc.contributor.nonIdAuthor | Elfadi, Ahmed | - |
dc.contributor.nonIdAuthor | Ullah, H M Arif | - |
dc.contributor.nonIdAuthor | Chung, Myung-Jin | - |
dc.contributor.nonIdAuthor | Son, Ji-Yoon | - |
dc.contributor.nonIdAuthor | Yun, Hyun Ho | - |
dc.contributor.nonIdAuthor | Park, Jae-Min | - |
dc.contributor.nonIdAuthor | Yim, Jae-Hyuk | - |
dc.contributor.nonIdAuthor | Jung, Seung-Jun | - |
dc.contributor.nonIdAuthor | Kim, Sang-Hyup | - |
dc.contributor.nonIdAuthor | Choi, Young-Chul | - |
dc.contributor.nonIdAuthor | Kim, Dae-Seong | - |
dc.contributor.nonIdAuthor | Shin, Jin-Hong | - |
dc.contributor.nonIdAuthor | Park, Jin-Sung | - |
dc.contributor.nonIdAuthor | Hur, Keun | - |
dc.contributor.nonIdAuthor | Lee, Sang-Han | - |
dc.contributor.nonIdAuthor | Lee, Eun-Joo | - |
dc.contributor.nonIdAuthor | Hwang, Daehee | - |
dc.contributor.nonIdAuthor | Jeong, Kyu-Shik | - |
dc.identifier.citationVolume | 7 | - |
dc.identifier.citationNumber | 1 | - |
dc.identifier.citationStartPage | 1 | - |
dc.identifier.citationTitle | Cell Death Discovery | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordPlus | NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | CIRCADIAN-RHYTHMS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | GLYCOPROTEIN | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | CLOCK | - |
dc.subject.keywordPlus | MYOD | - |
dc.contributor.affiliatedAuthor | Park, SunYoung | - |
dc.contributor.affiliatedAuthor | Park, Ji Hwan | - |
dc.contributor.affiliatedAuthor | Kang, Un-Beom | - |
dc.contributor.affiliatedAuthor | Choi, Seong-Kyoon | - |
dc.contributor.affiliatedAuthor | Elfadi, Ahmed | - |
dc.contributor.affiliatedAuthor | Ullah, H M Arif | - |
dc.contributor.affiliatedAuthor | Chung, Myung-Jin | - |
dc.contributor.affiliatedAuthor | Son, Ji-Yoon | - |
dc.contributor.affiliatedAuthor | Yun, Hyun Ho | - |
dc.contributor.affiliatedAuthor | Park, Jae-Min | - |
dc.contributor.affiliatedAuthor | Yim, Jae-Hyuk | - |
dc.contributor.affiliatedAuthor | Jung, Seung-Jun | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Hyup | - |
dc.contributor.affiliatedAuthor | Choi, Young-Chul | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Seong | - |
dc.contributor.affiliatedAuthor | Shin, Jin-Hong | - |
dc.contributor.affiliatedAuthor | Park, Jin-Sung | - |
dc.contributor.affiliatedAuthor | Hur, Keun | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Han | - |
dc.contributor.affiliatedAuthor | Lee, Eun-Joo | - |
dc.contributor.affiliatedAuthor | Hwang, Daehee | - |
dc.contributor.affiliatedAuthor | Jeong, Kyu-Shik | - |