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Development of a Real-Time Multimodal 3D Endoscope for Detection of Various Gastric Lesions

Title
Development of a Real-Time Multimodal 3D Endoscope for Detection of Various Gastric Lesions
Translated Title
위암 검출을 위한 실시간 3 차원 다중모드 내시경시스템 개발에 관한 연구
Authors
Youn, Se hyo
DGIST Authors
Youn, Se hyo; Hwang, Jae Youn; Song, Cheol
Advisor(s)
Hwang, Jae Youn
Co-Advisor(s)
Song, Cheol
Issue Date
2016
Available Date
2016-02-12
Degree Date
2016. 2
Type
Thesis
Keywords
Multimodal imagingauto-fluorescencemultispectral3D imaginghigh frequency ultrasound imagingcancer detection멀티모달 이미징자기 형광다중 분광3 차원 이미징고주파 초음파 이미징
Abstract
We built a multimodal endoscopic imaging system capable of fluorescence intensity, reflec-tance/fluorescence multi-spectral, and real-time 3-dimensional (3D) stereoscopic imaging for detection of gastric lesions. The system consists of two fiber bundles where GRIN Lens are attached to the end of them for collection of light from a region of interest, an objective lens for relaying of the collected light into a high sensitive CCD camera, optical bandpass filters included in a filter wheel, a servo-motor for selection of the bandpass filter, a beamsplitter, and etc. Also, a system control program was developed in order to perform fluorescence, multispectral, and 3-D stereoscopic imaging. Moreover, an ultrasound biomicroscopic system was developed for acquisition of a B-mode ultrasound image of a gastric lesion. It will be incorporated with the multimodal endoscopic system we developed. The capability of each imaging modality was here evalu-ated with tissue phantoms and then it was applied to image GI tumors ex-vivo in order to investigate its po-tential to discriminate between tumors and normal regions. The images obtained using each imaging modali-ty showed that the tumor regions were clearly distinguished from the normal regions. Altogether, our devel-oped system here allowed to obtain different but complementary information on lesions of interest such as auto-fluorescence intensity, spectral signatures, 3D surface curvatures and invasion depth of the lesions, thus may enhance the contrast in the early detection of gastric lesions. ⓒ 2016 DGIST
Table Of Contents
1. INTRODUCTION 1 -- 2. METHOD 5 -- 2.1 Configuration of the total system 5 -- 2.2 Connection between Optical fiber bundle and GRIN Lens 6 -- 2.3 Multi-spectral reflectance imaging system 7 -- 2.4 Fluorescence intensity imaging system 8 -- 2.5 Multi-spectral fluorescence intensity imaging system 8 -- 2.6 3-Dimensional stereoscopic imaging system 8 -- 2.7 Software 10 -- 2.8 Circuit 11 -- 2.9 Ultrasound Biomicroscopy 12 -- 3. PHANTOM EXPERIMENT 14 -- 3.1 Make a phantom 14 -- 3.2 Reflectance imaging 14 -- 3.3 Fluorescence and fluorescence spectral imaging 15 -- 3.4 Ultrasound Biomicroscopy imaging 16 -- 3.5 3-Dimensional stereoscopic imaging 16 -- 3.6 GPU speed experiment 17 -- 4. TUMOR ex vivo EXPERIMENT 18 -- 5. DISCUSSION and CONCLUSIONS 20 -- 6. REFERENCE 21 -- 7. APPENDIX 26
URI
http://dgist.dcollection.net/jsp/common/DcLoOrgPer.jsp?sItemId=000002230059
http://hdl.handle.net/20.500.11750/1451
DOI
10.22677/thesis.2230059
Degree
Master
Department
Information and Communication Engineering
University
DGIST
Files:
Collection:
Information and Communication EngineeringThesesMaster


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