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C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
- C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
- Hahm, JH[Hahm, Jeong-Hoon]; Kim, S[Kim, Sunhee]; DiLoreto, R[DiLoreto, Race]; Shi, C[Shi, Cheng]; Lee, SJV[Lee, Seung-Jae V.]; Murphy, CT[Murphy, Coleen T.]; Nam, HG[Nam, Hong Gil]
- DGIST Authors
- Nam, HG[Nam, Hong Gil]
- Issue Date
- Nature Communications, 6
- Article Type
- Aging; Caenorhabditis Elegans; Controlled Study; Food Intake; Gene Expression; Gene Mutation; Genetic Analysis; Genetic Variation; Hormone; Insulin Receptor; Life Extension; Lifespan; Longevity; Movement; Mutation; Nematode; Non-Human; Peptide; Physical Capacity; Physical Performance; Signal Transduction; Somatomedin C
- Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple method to assess C. elegans maximum physical ability based on the worms' maximum movement velocity. We show maximum velocity declines with age, correlates well with longevity, accurately reports movement ability and, if measured in mid-adulthood, is predictive of maximal lifespan. Contrary to recent findings, we observe that maximum velocity of worm with mutations in daf-2(e1370) insulin/IGF-1 signalling scales with lifespan. Because of increased odorant receptor expression, daf-2(e1370) mutants prefer food over exploration, causing previous on-food motility assays to underestimate movement ability and, thus, worm health. Finally, a disease-burden analysis of published data reveals that the daf-2(e1370) mutation improves quality of life, and therefore combines lifespan extension with various signs of an increased healthspan. © 2015 Macmillan Publishers Limited. All rights reserved.
- NATURE PUBLISHING GROUP
- Related Researcher
Nam, Hong Gil
CBRG(Complex Biology Research Group)
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