Cited 22 time in webofscience Cited 23 time in scopus

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

Title
C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation
Authors
Hahm, JH[Hahm, Jeong-Hoon]Kim, S[Kim, Sunhee]DiLoreto, R[DiLoreto, Race]Shi, C[Shi, Cheng]Lee, SJV[Lee, Seung-Jae V.]Murphy, CT[Murphy, Coleen T.]Nam, HG[Nam, Hong Gil]
DGIST Authors
Nam, HG[Nam, Hong Gil]
Issue Date
2015-11
Citation
Nature Communications, 6
Type
Article
Article Type
Article
Keywords
AgingCaenorhabditis ElegansControlled StudyFood IntakeGene ExpressionGene MutationGenetic AnalysisGenetic VariationHormoneInsulin ReceptorLife ExtensionLifespanLongevityMovementMutationNematodeNon-HumanPeptidePhysical CapacityPhysical PerformanceSignal TransductionSomatomedin C
ISSN
2041-1723
Abstract
Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple method to assess C. elegans maximum physical ability based on the worms' maximum movement velocity. We show maximum velocity declines with age, correlates well with longevity, accurately reports movement ability and, if measured in mid-adulthood, is predictive of maximal lifespan. Contrary to recent findings, we observe that maximum velocity of worm with mutations in daf-2(e1370) insulin/IGF-1 signalling scales with lifespan. Because of increased odorant receptor expression, daf-2(e1370) mutants prefer food over exploration, causing previous on-food motility assays to underestimate movement ability and, thus, worm health. Finally, a disease-burden analysis of published data reveals that the daf-2(e1370) mutation improves quality of life, and therefore combines lifespan extension with various signs of an increased healthspan. © 2015 Macmillan Publishers Limited. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/1562
DOI
10.1038/ncomms9919
Publisher
NATURE PUBLISHING GROUP
Related Researcher
Files:
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Collection:
New BiologyETC1. Journal Articles


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