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A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells
- A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells
- Ahmed, N[Ahmed, Nisar]; Shirinfar, B[Shirinfar, Bahareh]; Miriyala, VM[Miriyala, Vijay Madhav]; Choi, SK[Choi, Seong-Kyoon]; Lee, KM[Lee, Kyeong-Min]; Jeon, WB[Jeon, Won Bae]; Park, YS[Park, Yu Shin]; Nam, HG[Nam, Hong Gil]
- DGIST Authors
- Choi, SK[Choi, Seong-Kyoon]; Lee, KM[Lee, Kyeong-Min]; Jeon, WB[Jeon, Won Bae]; Park, YS[Park, Yu Shin]; Nam, HG[Nam, Hong Gil]
- Issue Date
- Supramolecular Chemistry, 27(7-8), 478-483
- Article Type
- Cationic Probe; Confocal Microscopy; Host-Guest Chemistry; RNA Recognition
- Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membrane-permeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson's disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology. © 2014 © 2014 Taylor & Francis.
- Taylor and Francis Ltd.
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