Cited 4 time in webofscience Cited 3 time in scopus

A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells

Title
A new selective 'turn-on' small fluorescent cationic probe for recognition of RNA in cells
Authors
Ahmed, N[Ahmed, Nisar]Shirinfar, B[Shirinfar, Bahareh]Miriyala, VM[Miriyala, Vijay Madhav]Choi, SK[Choi, Seong-Kyoon]Lee, KM[Lee, Kyeong-Min]Jeon, WB[Jeon, Won Bae]Park, YS[Park, Yu Shin]Nam, HG[Nam, Hong Gil]
DGIST Authors
Choi, SK[Choi, Seong-Kyoon]; Lee, KM[Lee, Kyeong-Min]Jeon, WB[Jeon, Won Bae]; Park, YS[Park, Yu Shin]; Nam, HG[Nam, Hong Gil]
Issue Date
2015-08-03
Citation
Supramolecular Chemistry, 27(7-8), 478-483
Type
Article
Article Type
Article
Keywords
Cationic ProbeConfocal MicroscopyHost-Guest ChemistryRNA Recognition
ISSN
1061-0278
Abstract
Fluorescent imaging probes have revolutionised cell biology by monitoring cellular objects. However, the lack of fluorescent probes with high selectivity for RNA has been a drawback. Thus, selective RNA binding for fluorescent sensors is essential. Here, we report the selective fluorescence enhancement upon addition of RNA. By exploiting a selective recognition of small tetra-cationic probe 1 for RNA, we also explain the possible binding mode for RNA. As a membrane-permeant fluorescence probe, 1 provides selective imaging of RNA not only in human neuroblastoma tumour SH-SY5Y cell line used for Parkinson's disease but also in the unicellular green alga cells. Further exploitation could open new opportunities in neurotoxin and cancer biology. © 2014 © 2014 Taylor & Francis.
URI
http://hdl.handle.net/20.500.11750/1567
DOI
10.1080/10610278.2014.989851
Publisher
Taylor and Francis Ltd.
Related Researcher
Files:
There are no files associated with this item.
Collection:
Center for Core Research Facilities1. Journal Articles
New BiologyCBRG(Complex Biology Research Group)1. Journal Articles


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