Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Davin | - |
| dc.contributor.author | Seo, Jinsoo | - |
| dc.contributor.author | Jeong, Hae Chan | - |
| dc.contributor.author | Lee, Hyosang | - |
| dc.contributor.author | Lee, Sung Bae | - |
| dc.date.accessioned | 2021-12-28T07:00:02Z | - |
| dc.date.available | 2021-12-28T07:00:02Z | - |
| dc.date.created | 2021-11-17 | - |
| dc.date.issued | 2021-11 | - |
| dc.identifier.citation | Frontiers in Molecular Neuroscience, v.14 | - |
| dc.identifier.issn | 1662-5099 | - |
| dc.identifier.uri | http://hdl.handle.net/20.500.11750/15977 | - |
| dc.description.abstract | The lack of early diagnostic biomarkers for schizophrenia greatly limits treatment options that deliver therapeutic agents to affected cells at a timely manner. While previous schizophrenia biomarker research has identified various biological signals that are correlated with certain diseases, their reliability and practicality as an early diagnostic tool remains unclear. In this article, we discuss the use of atypical epigenetic and/or consequent transcriptional alterations (ETAs) as biomarkers of early-stage schizophrenia. Furthermore, we review the viability of discovering and applying these biomarkers through the use of cutting-edge technologies such as human induced pluripotent stem cell (iPSC)-derived neurons, brain models, and single-cell level analyses. Copyright © 2021 Lee, Seo, Jeong, Lee and Lee. | - |
| dc.language | English | - |
| dc.publisher | Frontiers Media S.A. | - |
| dc.title | The Perspectives of Early Diagnosis of Schizophrenia Through the Detection of Epigenomics-Based Biomarkers in iPSC-Derived Neurons | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.3389/fnmol.2021.756613 | - |
| dc.identifier.wosid | 000726115300001 | - |
| dc.identifier.scopusid | 2-s2.0-85120418330 | - |
| dc.type.local | Article(Overseas) | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.citation.publicationname | Frontiers in Molecular Neuroscience | - |
| dc.contributor.nonIdAuthor | Lee, Davin | - |
| dc.contributor.nonIdAuthor | Jeong, Hae Chan | - |
| dc.identifier.citationVolume | 14 | - |
| dc.identifier.citationTitle | Frontiers in Molecular Neuroscience | - |
| dc.description.isOpenAccess | Y | - |
| dc.subject.keywordAuthor | schizophrenia | - |
| dc.subject.keywordAuthor | iPSC | - |
| dc.subject.keywordAuthor | organoid | - |
| dc.subject.keywordAuthor | epigenetic alteration | - |
| dc.subject.keywordAuthor | transcriptional alteration | - |
| dc.subject.keywordPlus | PLURIPOTENT STEM-CELLS | - |
| dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
| dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
| dc.subject.keywordPlus | GRAY-MATTER | - |
| dc.subject.keywordPlus | 1ST-EPISODE SCHIZOPHRENIA | - |
| dc.subject.keywordPlus | TRANSCRIPTOME ANALYSIS | - |
| dc.subject.keywordPlus | HIPPOCAMPAL ACTIVITY | - |
| dc.subject.keywordPlus | MISMATCH NEGATIVITY | - |
| dc.subject.keywordPlus | DOPAMINE FUNCTION | - |
| dc.subject.keywordPlus | GENE-EXPRESSION | - |
| dc.contributor.affiliatedAuthor | Lee, Davin | - |
| dc.contributor.affiliatedAuthor | Seo, Jinsoo | - |
| dc.contributor.affiliatedAuthor | Jeong, Hae Chan | - |
| dc.contributor.affiliatedAuthor | Lee, Hyosang | - |
| dc.contributor.affiliatedAuthor | Lee, Sung Bae | - |
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