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MicroRNAs in brain aging

Title
MicroRNAs in brain aging
Authors
Danka Mohammed, C.P.[Danka Mohammed, Chand Parvez]Park, J.S.[Park, Jun Soo]Nam, H.G.[Nam, Hong Gil]Kim, K.[Kim, Kee Tae]
DGIST Authors
Danka Mohammed, C.P.[Danka Mohammed, Chand Parvez]; Park, J.S.[Park, Jun Soo]; Nam, H.G.[Nam, Hong Gil]; Kim, K.[Kim, Kee Tae]
Issue Date
2017
Citation
Mechanisms of Ageing and Development
Type
Article
Article Type
Article in Press
Keywords
AgingBrainDysregulationMicroRNATarget
ISSN
0047-6374
Abstract
Brain aging is one of the most crucial biological processes that affect the physiological balance between health and disease. Age-associated dysfunction of brain leads to severe health problems in current aging society. MicroRNAs (miRNAs) have emerged as important regulators in most physiological processes including fine-tuning of the short-term, cellular regulatory functions as well as modulation of long-term organismal lifespan. In this review, we discuss critical roles of miRNAs in the progression of normal and pathological brain aging. 50% of all known miRNAs are found in brain including cortex and hippocampus. A significant number of expressed miRNAs were differentially regulated during aging, implicating miRNAs as regulators of brain aging. The ability of miRNAs to regulate multiple targets within a pathway or even multiple pathways allows for coordinated regulation of brain functions. miRNA-mediated, brain functional changes are evident in cognition, inflammation, neuroprotection, lipid metabolism, mitochondrial function and lifespan. Dysregulation of brain miRNAs contributes to accelerated cognitive decline and increased neurological disorders. Elucidating mechanisms by which miRNAs and their multiple targets are temporally and spatially regulated in normal and pathological brain aging will provide a deeper understanding on the process of interrelated pathways of brain aging, and a new insight into therapeutic interventions. © 2017 Elsevier B.V.
URI
http://hdl.handle.net/20.500.11750/1598
DOI
10.1016/j.mad.2017.01.007
Publisher
Elsevier Ltd
Related Researcher
Files:
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Collection:
ETCETC
New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
ETC1. Journal Articles


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