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Balanced Nucleocytosolic Partitioning Defines a Spatial Network to Coordinate Circadian Physiology in Plants
- Balanced Nucleocytosolic Partitioning Defines a Spatial Network to Coordinate Circadian Physiology in Plants
- Kim, Y[Kim, Yumi]; Han, S[Han, Seungmin]; Yeom, M[Yeom, Miji]; Kim, H[Kim, Hyunmin]; Lim, J[Lim, Junhyun]; Cha, JY[Cha, Joon-Yung]; Kim, WY[Kim, Woe-Yeon]; Somers, DE[Somers, David E.]; Putterill, J[Putterill, Joanna]; Nam, HG[Nam, Hong Gil]; Hwang, D[Hwang, Daehee]
- DGIST Authors
- Kim, Y[Kim, Yumi]; Nam, HG[Nam, Hong Gil]
- Issue Date
- Developmental Cell, 26(1), 73-85
- Article Type
- Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Circadian Rhythm; Computer Simulation; Cytosol; DNA-Binding Proteins; DNA, Plant; Flowers; Gene; Gene Expression Regulation, Plant; Genes, Plant; Gigantea; Intracellular Space; LHY Gene; Mathematical Model; Models, Biological; Noise; Nucleotide Sequence; Photosynthesis; Plant Leaves; Priority Journal; Protein Interaction Domains and Motifs; Transcription Factors
- Biological networks consist of a defined set of regulatory motifs. Subcellular compartmentalization of regulatory molecules can provide a further dimension in implementing regulatory motifs. However, spatial regulatory motifs and their roles in biological networks have rarely been explored. Here we show, using experimentation and mathematical modeling, that spatial segregation of GIGANTEA (GI), a critical component of plant circadian systems, into nuclear and cytosolic compartments leads to differential functions as positive and negative regulators of the circadian core gene, LHY, forming an incoherent feedforward loop to regulate LHY. This regulatory motif formed by nucleocytoplasmic partitioning ofGI confers, through the balanced operation of the nuclear and cytosolic GI, strong rhythmicity and robustness to external and internal noises to the circadian system. Our results show that spatial and functional segregation of a single molecule species into different cellular compartments provides a means for extending the regulatory capabilities of biological networks. © 2013 Elsevier Inc.
- Cell Press
- Related Researcher
Nam, Hong Gil
CBRG(Complex Biology Research Group)
Plant Senescence and Life History; Systems Biology; Complexbiology
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- Department of New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
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