Cited 32 time in webofscience Cited 34 time in scopus

ELF4 Regulates GIGANTEA Chromatin Access through Subnuclear Sequestration

Title
ELF4 Regulates GIGANTEA Chromatin Access through Subnuclear Sequestration
Authors
Kim, Y[Kim, Yumi]Lim, J[Lim, Junhyun]Yeom, M[Yeom, Miji]Kim, H[Kim, Hyunmin]Kim, J[Kim, Jeongsik]Wang, L[Wang, Lei]Kim, WY[Kim, Woe Yeon]Somers, DE[Somers, David E.]Nam, HG[Nam, Hong Gil]
DGIST Authors
Kim, Y[Kim, Yumi]; Lim, J[Lim, Junhyun]; Yeom, M[Yeom, Miji]; Kim, H[Kim, Hyunmin]Nam, HG[Nam, Hong Gil]
Issue Date
2013-03
Citation
Cell Reports, 3(3), 671-677
Type
Article
Article Type
Article
Keywords
Active Transport, Cell NucleusArabidopsisArabidopsis ProteinsBinding AffinityCell CompartmentalizationCell NucleusCell Nucleus Inclusion BodyCellular DistributionChromatinCircadian RhythmConstans GeneControlled StudyDNA-Binding ProteinsEarly Flowering 4 GeneFloweringGigantea GeneNon-HumanPhotoperiodicityPlant GenePriority JournalPromoter RegionPromoter Regions, GeneticProtein BindingTranscription Factors
ISSN
2211-1247
Abstract
Many organisms, including plants, use the circadian clock to measure the duration of day and night. Daily rhythms in the plant circadian system are generated by multiple interlocked transcriptional/translational loops and also by spatial regulations such as nuclear translocation. GIGANTEA (GI), one of the key clock components in Arabidopsis, makes distinctive nuclear bodies like other nuclear-localized circadian regulators. However, little is known about the dynamics or roles of GI subnuclear localization. Here, we characterize GI subnuclear compartmentalization and identify unexpected dynamic changes under diurnal conditions. We further identify EARLY FLOWERING 4 (ELF4) as a regulator of GI nuclear distribution through a physical interaction. ELF4 sequesters GI from the nucleoplasm, where GI binds the promoter of CONSTANS (. CO), to discrete nuclear bodies. We suggest that the subnuclear compartmentalization of GI by ELF4 contributes to the regulation of photoperiodic flowering.
URI
http://hdl.handle.net/20.500.11750/1609
DOI
10.1016/j.celrep.2013.02.021
Publisher
Cell Press
Related Researcher
Files:
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Collection:
ETCETC
Division of Nano∙Energy Convergence Research1. Journal Articles
New BiologyETC1. Journal Articles
ETC1. Journal Articles


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