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Nano-patterned SU-8 surface using nanosphere-lithography for enhanced neuronal cell growth

Title
Nano-patterned SU-8 surface using nanosphere-lithography for enhanced neuronal cell growth
Authors
Kim, E[Kim, Eunhee]Yoo, SJ[Yoo, Seung-Jun]Kim, E[Kim, Eunjung]Kwon, TH[Kwon, Tae-Hwan]Zhang, L[Zhang, Li]Moon, C[Moon, Cheil]Choi, H[Choi, Hongsoo]
DGIST Authors
Kim, E[Kim, Eunhee]; Yoo, SJ[Yoo, Seung-Jun]; Moon, C[Moon, Cheil]Choi, H[Choi, Hongsoo]
Issue Date
2016-04-29
Citation
Nanotechnology, 27(17)
Type
Article
Article Type
Article
Keywords
Amino AcidsCell CultureCell Culture MediumsCellsCytologyExtracellular MatricesImplants (Surgical)LithographyNano-PatternedNano-Scale SurfacesNano Sphere LithographyNanosphere Lithography (NSl)NanospheresNeurite OutgrowthNeuronal DevelopmentNeuronsPlastic CoatingsPolystyrene NanoparticlesSurface ModificationSurface Treatment
ISSN
0957-4484
Abstract
Mimicking the nanoscale surface texture of the extracellular matrix can affect the regulation of cellular behavior, including adhesion, differentiation, and neurite outgrowth. In this study, SU-8-based polymer surfaces with well-ordered nanowell arrays were fabricated using nanosphere lithography with polystyrene nanoparticles. We show that the SU-8 surface with nanowells resulted in similar neuronal development of rat pheochromocytoma (PC12) cells compared with an unpatterned poly-L-lysine (PLL)-coated SU-8 surface. Additionally, even after soaking the substrate in cell culture medium for two weeks, cells on the nanowell SU-8 surface showed long-term neurite outgrowth compared to cells on the PLL-coated SU-8 surface. The topographical surface modification of the nanowell array demonstrates potential as a replacement for cell adhesive material coatings such as PLL, for applications requiring long-term use of polymer-based implantable devices. © 2016 IOP Publishing Ltd.
URI
http://hdl.handle.net/20.500.11750/1643
DOI
10.1088/0957-4484/27/17/175303
Publisher
Institute of Physics Publishing
Related Researcher
Files:
There are no files associated with this item.
Collection:
Brain and Cognitive SciencesMoon Lab1. Journal Articles
Robotics EngineeringETC1. Journal Articles


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