Cited 6 time in webofscience Cited 8 time in scopus

The short-lived African turquoise killifish: an emerging experimental model for ageing

Title
The short-lived African turquoise killifish: an emerging experimental model for ageing
Authors
Kim, Y[Kim, Yumi]Nam, HG[Nam, Hong Gil]Valenzano, DR[Valenzano, Dario Riccardo]
DGIST Authors
Kim, Y[Kim, Yumi]; Nam, HG[Nam, Hong Gil]
Issue Date
2016-02-01
Citation
Disease Models and Mechanisms, 9(2), 115-129
Type
Article
Article Type
Review
Keywords
Age-Associated DiseasesAgeingLongevityModel OrganismsNothobranchius FurzeriTurquoise Killifish
ISSN
1754-8403
Abstract
Human ageing is a fundamental biological process that leads to functional decay, increased risk for various diseases and, ultimately, death. Some of the basic biological mechanisms underlying human ageing are shared with other organisms; thus, animal models have been invaluable in providing key mechanistic and molecular insights into the common bases of biological ageing. In this Review, we briefly summarise the major applications of the most commonly used model organisms adopted in ageing research and highlight their relevance in understanding human ageing. We compare the strengths and limitations of different model organisms and discuss in detail an emerging ageing model, the short-lived African turquoise killifish. We review the recent progress made in using the turquoise killifish to study the biology of ageing and discuss potential future applications of this promising animal model. © 2016 Published by The Company of Biologists Ltd.
URI
http://hdl.handle.net/20.500.11750/1645
DOI
10.1242/dmm.023226
Publisher
Company of Biologists Ltd
Related Researcher
Files:
There are no files associated with this item.
Collection:
New BiologyETC1. Journal Articles


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