Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hille, Bertil | - |
dc.contributor.author | Dickson, Eamonn J. | - |
dc.contributor.author | Kruse, Martin | - |
dc.contributor.author | Vivas, Oscar | - |
dc.contributor.author | Suh, Byung Chang | - |
dc.date.available | 2017-05-11T01:47:40Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1388-1981 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/1662 | - |
dc.description.abstract | Abstract Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides. © 2014 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Phosphoinositides regulate ion channels | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbalip.2014.09.010 | - |
dc.identifier.scopusid | 2-s2.0-84928336019 | - |
dc.identifier.bibliographicCitation | Biochimica Et Biophysica Acta: Molecular and Cell Biology of Lipids, v.1851, no.6, pp.844 - 856 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Phosphatidylinositol 4,5-bisphosphate | - |
dc.subject.keywordAuthor | Phospholipase C (PLC) | - |
dc.subject.keywordAuthor | G-protein coupled receptor (GPCR) | - |
dc.subject.keywordAuthor | Potassium channel | - |
dc.subject.keywordAuthor | Calcium channel | - |
dc.subject.keywordAuthor | Transient receptor potential channel (TRP channel) | - |
dc.subject.keywordPlus | ACTIVATED CA2+ CHANNELS | - |
dc.subject.keywordPlus | Calcium Channel | - |
dc.subject.keywordPlus | Calcium Channels | - |
dc.subject.keywordPlus | Cell Membrane | - |
dc.subject.keywordPlus | Chemistry | - |
dc.subject.keywordPlus | Chloride Channel | - |
dc.subject.keywordPlus | Chloride Channels | - |
dc.subject.keywordPlus | EPITHELIAL NA+ CHANNEL | - |
dc.subject.keywordPlus | Epithelial Sodium Channel | - |
dc.subject.keywordPlus | Epithelial Sodium Channels | - |
dc.subject.keywordPlus | G-BETA-GAMMA | - |
dc.subject.keywordPlus | G-Protein Coupled Receptor (GPCR) | - |
dc.subject.keywordPlus | G Protein Coupled Receptor | - |
dc.subject.keywordPlus | Gene Expression Regulation | - |
dc.subject.keywordPlus | Genetics | - |
dc.subject.keywordPlus | Human | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Ion Transport | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | MemBRANE PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | - |
dc.subject.keywordPlus | Metabolism | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | - |
dc.subject.keywordPlus | Phosphatidylinositol 4,5-Diphosphate | - |
dc.subject.keywordPlus | Phosphatidylinositol 4,5 Bisphosphate | - |
dc.subject.keywordPlus | Phospholipase C | - |
dc.subject.keywordPlus | Phospholipase C (PLC) | - |
dc.subject.keywordPlus | PLASMA-MemBRANE | - |
dc.subject.keywordPlus | Potassium Channel | - |
dc.subject.keywordPlus | Potassium Channels | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | RAT SYMPATHETIC NEURONS | - |
dc.subject.keywordPlus | Receptors, G-Protein-Coupled | - |
dc.subject.keywordPlus | RECTIFYING K+ CHANNELS | - |
dc.subject.keywordPlus | Signal Transduction | - |
dc.subject.keywordPlus | Transient Receptor Potential Channel | - |
dc.subject.keywordPlus | Transient Receptor Potential Channel (Trp Channel) | - |
dc.subject.keywordPlus | Transient Receptor Potential Channels | - |
dc.subject.keywordPlus | Type C Phospholipases | - |
dc.citation.endPage | 856 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 844 | - |
dc.citation.title | Biochimica Et Biophysica Acta: Molecular and Cell Biology of Lipids | - |
dc.citation.volume | 1851 | - |
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