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Selective Fluorescent Detection of RNA in Living Cells by Using Imidazolium-Based Cyclophane

Title
Selective Fluorescent Detection of RNA in Living Cells by Using Imidazolium-Based Cyclophane
Authors
Shirinfar, B[Shirinfar, Bahareh]Ahmed, N[Ahmed, Nisar]Park, YS[Park, Yu Shin]Cho, GS[Cho, Gun-Sik]Youn, IS[Youn, Il Seung]Han, JK[Han, Jin-Kwan]Nam, HG[Nam, Hong Gil]Kim, KS[Kim, Kwang S.]
DGIST Authors
Park, YS[Park, Yu Shin]; Nam, HG[Nam, Hong Gil]
Issue Date
2013-01-09
Citation
Journal of the American Chemical Society, 135(1), 90-93
Type
Article
Article Type
Article
Keywords
Animal CellAnimal ModelAnimalsAqueous SolutionAromatic MoietiesCaenorhabditis ElegansChelationChemical StructureChemosensorControlled StudyCyclophane DerivativeCyclophanesCytosolFluorescenceFluorescence EnhancementFluorescence ImageFluorescent DetectionFluorescent DyesH-BondingHela CellHela CellsHumansHydrogenHydrogen BondImidazole DerivativeImidazolesLiving CellMacrocyclic CompoundsNaphthaleneNon-HumanOnionspHPhosphatePhysiological pHPhysiologyProtonProton Nuclear Magnetic ResonanceRNARNA BindingRNA DegradationStatic ElectricityStoichiometrySynthesis
ISSN
0002-7863
Abstract
A water-soluble imidazolium-based fluorescent chemosensor senses RNA selectively through fluorescence enhancement over other biologically relevant biomolecules in aqueous solution at physiological pH 7.4. Fluorescence image detection of RNA in living cells such as onion cells, HeLa cells, and animal model cells was successfully demonstrated which displays a chelation-enhanced fluorescence effect. These affinities can be attributed to the strong electrostatic (C-H)+⋯A- ionic H-bonding and the aromatic moiety driven π-stacking of imidazolium-based cyclophane with the size-complementary major groove of RNA. © 2012 American Chemical Society.
URI
http://hdl.handle.net/20.500.11750/1700
DOI
10.1021/ja3112274
Publisher
American Chemical Society
Related Researcher
Files:
There are no files associated with this item.
Collection:
New BiologyCBRG(Complex Biology Research Group)1. Journal Articles
New BiologyETC1. Journal Articles


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