Selective Fluorescent Detection of RNA in Living Cells by Using Imidazolium-Based Cyclophane
- Title
- Selective Fluorescent Detection of RNA in Living Cells by Using Imidazolium-Based Cyclophane
- Author(s)
- Shirinfar, Bahareh ; Ahmed, Nisar ; Park, Yu Shin ; Cho, Gun-Sik ; Youn, Il Seung ; Han, Jin-Kwan ; Nam, Hong Gil ; Kim, Kwang S.
- Issued Date
- 2013-01
- Citation
- Journal of the American Chemical Society, v.135, no.1, pp.90 - 93
- Type
- Article
- Keywords
- IN-SITU HYBRIDIZATION ; MESSENGER-RNA ; AQUEOUS-SOLUTION ; ANION RECOGNITION ; EXCIMER FORMATION ; RECEPTORS ; PROBES ; CHEMOSENSOR ; BINDING ; DRIVEN
- ISSN
- 0002-7863
- Abstract
- A water-soluble imidazolium-based fluorescent chemosensor senses RNA selectively through fluorescence enhancement over other biologically relevant biomolecules in aqueous solution at physiological pH 7.4. Fluorescence image detection of RNA in living cells such as onion cells, HeLa cells, and animal model cells was successfully demonstrated which displays a chelation-enhanced fluorescence effect. These affinities can be attributed to the strong electrostatic (C-H)+⋯A- ionic H-bonding and the aromatic moiety driven π-stacking of imidazolium-based cyclophane with the size-complementary major groove of RNA. © 2012 American Chemical Society.
- Publisher
- AMER CHEMICAL SOC
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- Appears in Collections:
- Department of New Biology CBRG(Complex Biology Research Group) 1. Journal Articles
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