Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Jeon, Seong Gak | - |
dc.contributor.author | Jeong, Ha-Ram | - |
dc.contributor.author | Park, HyunHee | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.contributor.author | Hoe, Hyang-Sook | - |
dc.date.accessioned | 2023-01-17T13:40:16Z | - |
dc.date.available | 2023-01-17T13:40:16Z | - |
dc.date.created | 2022-12-01 | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/17468 | - |
dc.description.abstract | Ca2+ signaling is implicated in the transition between microglial surveillance and activation. Several L-type Ca2+ channel blockers (CCBs) have been shown to ameliorate neuroinflammation by modulating microglial activity. In this study, we examined the effects of the L-type CCB felodipine on LPS-mediated proinflammatory responses. We found that felodipine treatment significantly diminished LPS-evoked proinflammatory cytokine levels in BV2 microglial cells in an L-type Ca2+ channel-dependent manner. In addition, felodipine leads to the inhibition of TLR4/AKT/STAT3 signaling in BV2 microglial cells. We further examined the effects of felodipine on LPS-stimulated neuroinflammation in vivo and found that daily administration (3 or 7 days, i.p.) significantly reduced LPS-mediated gliosis and COX-2 and IL-1β levels in C57BL/6 (wild-type) mice. Moreover, felodipine administration significantly reduced chronic neuroinflammation-induced spatial memory impairment, dendritic spine number, and microgliosis in C57BL/6 mice. Taken together, our results suggest that the L-type CCB felodipine could be repurposed for the treatment of neuroinflammation/cognitive function-associated diseases. © 2022 by the authors. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | L-Type Ca2+ Channel Inhibition Rescues the LPS-Induced Neuroinflammatory Response and Impairments in Spatial Memory and Dendritic Spine Formation | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms232113606 | - |
dc.identifier.scopusid | 2-s2.0-85141642112 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.23, no.21 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | felodipine | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | gliosis | - |
dc.subject.keywordAuthor | neuroinflammation | - |
dc.subject.keywordAuthor | Ca2+ channel blocker | - |
dc.subject.keywordAuthor | spatial memory | - |
dc.subject.keywordPlus | CALCIUM-SENSING RECEPTOR | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | THERAPEUTIC TARGETS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | ION CHANNELS | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | FELODIPINE | - |
dc.citation.number | 21 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 23 | - |
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